Successful integration of an automated patient-reported outcome measure within a hospital electronic patient record.

Objectives: The objective of this evaluation was to assess the feasibility of implementing a fully integrated, automated, electronic patient-reported outcome measures (ePROM) system into a hospital electronic patient record (EPR; hospital-based clinical record). Additional objectives included evaluating the effect of the system on patient-reported outcome measures (PROM) completion rates and investigating the acceptability of the ePROM.

Methods: The evaluation was conducted in a rheumatology clinic in a specialist children's hospital in the UK.

The impact of paediatric dose range checking software.

Objective: Dosing errors can cause significant harm in paediatric healthcare settings. Our objective was to investigate the effects of paediatric dose range checking (DRC) clinical decision support (CDS) software on overdosing-related outcomes.

Methods: A before-after study and a semistructured survey of prescribers was conducted across inpatient wards (excluding intensive care) in a regional children's hospital.

Evaluating health information technologies: A systematic review of framework recommendations.

Objective: Evaluating Health Information Technologies (HITs) can be challenging, but studies are necessary so that the most beneficial interventions can be identified. Our objective was to systematically review the available recommendations for improving the methods used in HIT evaluations.

Methods: HIT evaluation frameworks were identified from database (MEDLINE, EMBASE, CINAHL) and grey literature searches.

Seizures and quinolone antibiotics in children: a systematic review of adverse events.

Background: Quinolone antibiotics have a broad spectrum of activity including against Gram-negative organisms (especially ), but their use has been associated with the development of seizures. Our objective was to evaluate the association between the administration of quinolones and seizures for three groups of children: those with epilepsy; those with other CNS disorders; and those without any CNS disorder.

Method: We conducted a systematic review of the MEDLINE, EMBASE and CENTRAL databases.

Patient-focused outcomes are infrequently reported in pediatric health information technology trials: a systematic review.

Objectives: Billions of dollars have been invested in Health Information Technologies (HITs), and randomized controlled trials (RCTs) have been conducted to identify the effects of these interventions. Our objective was to identify the types of outcomes that were measured and reported in these RCTs.

Study Design And Setting: We completed a systematic review (Medline, EMBASE, and CENTRAL databases) of RCTs involving children (<18 years) and utilizing HIT interventions.

A systematic review of the effects of implementing clinical pathways supported by health information technologies.

Objective: Health information technology (HIT) interventions include electronic patient records, prescribing, and ordering systems. Clinical pathways are multidisciplinary plans of care that enable the delivery of evidence-based healthcare. Our objective was to systematically review the effects of implementing HIT-supported clinical pathways.

Persisting fatigue and myalgia as the presenting features in a case of hypokalaemic periodic paralysis.

We report a case of a 9-year-old boy who developed hypokalaemic periodic paralysis (HypoPP) following a prodrome of persistent fatigue and muscle aches associated with mildly elevated creatine kinase (CK) levels.HypoPP is usually associated with a sudden onset of weakness and hypokalaemia at presentation. A review of published cases failed to identify any other reports of individuals with a similar onset of symptoms and elevated CK levels prior to the development of frank HypoPP.

Salbutamol or aminophylline for acute severe asthma: how to choose which one, when and why?

Acute, severe exacerbations of asthma present a challenge due to the significant morbidity associated with this presentation. For exacerbations that are refractory to initial treatments with inhaled and oral therapies, there is still doubt about which intravenous therapies are most likely to be helpful. β-2 agonists and aminophylline have differing mechanisms of action that also affect their adverse effects profiles and these are considered.