Impact of Overall and Specific Dimensions of Schizotypy on Theory of Mind.

Background: Impairments in theory of mind (ToM) are highly prevalent among individuals with schizophrenia, resulting in substantial functional deficits. However, research on impairments in individuals with schizotypy has yielded inconsistent findings, with some studies finding ToM deficits in overall schizotypy, other studies finding ToM deficits in only specific schizotypy dimensions, and yet other studies finding no ToM deficits at all. One potential key factor that may account for this discrepancy is the use of schizotypy measures that do not adequately measure specific schizotypy dimensions.

Repeated sprint training: The effects of session volume on acute physiological, neuromuscular, perceptual and performance outcomes in athletes.

We examined the effects of repeated sprint training (RST) session volume on acute physiological, neuromuscular, perceptual and performance outcomes. In a randomised, counterbalanced, and crossover design, 14 healthy and trained male and female athletes (age: 23 ± 3 years) completed two sets of 10 × 40 m (10 × 40), 5 × 40 m (5 × 40), 10 × 20 m (10 × 20) and 5 × 20 m (5 × 20) sprints with 30 s rest between repetitions and 3 min rest between sets for all protocols. Average and peak heart rate, average oxygen consumption (VO), time >90% of maximal oxygen consumption (VO), differential ratings of perceived exertion (RPE), session-RPE training load (sRPE-TL), percentage sprint decrement (S), acceleration load and distance >90% of maximal sprint speed were recorded during each session.

Anatomical Registration of Implanted Sensors Improves Accuracy of Trunk Tilt Estimates with a Networked Neuroprosthesis.

For individuals with spinal cord injuries (SCIs) above the midthoracic level, a common complication is the partial or complete loss of trunk stability in the seated position. Functional neuromuscular stimulation (FNS) can restore seated posture and other motor functions after paralysis by applying small electrical currents to the peripheral motor nerves. In particular, the Networked Neuroprosthesis (NNP) is a fully implanted, modular FNS system that is also capable of capturing information from embedded accelerometers for measuring trunk tilt for feedback control of stimulation.

The Acute Demands of Repeated-Sprint Training on Physiological, Neuromuscular, Perceptual and Performance Outcomes in Team Sport Athletes: A Systematic Review and Meta-analysis.

Background: Repeated-sprint training (RST) involves maximal-effort, short-duration sprints (≤ 10 s) interspersed with brief recovery periods (≤ 60 s). Knowledge about the acute demands of RST and the influence of programming variables has implications for training prescription.

Objectives: To investigate the physiological, neuromuscular, perceptual and performance demands of RST, while also examining the moderating effects of programming variables (sprint modality, number of repetitions per set, sprint repetition distance, inter-repetition rest modality and inter-repetition rest duration) on these outcomes.

δ C values of urinary 19-norandrosterone in antidoping samples and potential for adverse findings from boar offal consumption.

19-Norandrosterone (19NA) is the preferred urinary target compound to identify doping with nandrolone or related 19-norsteroids. At concentrations between 2.5 and 15 ng/mL, isotope ratio mass spectrometry (IRMS) is required to establish exogenous origin of urinary 19NA.

Confronting ethical and social issues related to the genetics of musicality.

New interdisciplinary research into genetic influences on musicality raises a number of ethical and social issues for future avenues of research and public engagement. The historical intersection of music cognition and eugenics heightens the need to vigilantly weigh the potential risks and benefits of these studies and the use of their outcomes. Here, we bring together diverse disciplinary expertise (complex trait genetics, music cognition, musicology, bioethics, developmental psychology, and neuroscience) to interpret and guide the ethical use of findings from recent and future studies.

Comparison of Sprint Timing Methods on Performance, and Displacement and Velocity at Timing Initiation.

Weakley, J, McCosker, C, Chalkley, D, Johnston, R, Munteanu, G, and Morrison, M. Comparison of sprint timing methods on performance, and displacement and velocity at timing initiation. J Strength Cond Res 37(1): 234-238, 2023-Sprint testing is commonly used to assess speed and acceleration in athletes.

Sleep, circadian biology and skeletal muscle interactions: Implications for metabolic health.

There currently exists a modern epidemic of sleep loss, triggered by the changing demands of our 21st century lifestyle that embrace 'round-the-clock' remote working hours, access to energy-dense food, prolonged periods of inactivity, and on-line social activities. Disturbances to sleep patterns impart widespread and adverse effects on numerous cells, tissues, and organs. Insufficient sleep causes circadian misalignment in humans, including perturbed peripheral clocks, leading to disrupted skeletal muscle and liver metabolism, and whole-body energy homeostasis.

Regulates Cell-Cell Adhesion and EMT and Inhibits Retinoblastoma Progression.

Retinoblastoma (RB) is the most common intraocular pediatric cancer. Nearly all cases of RB are associated with mutations compromising the function of the tumor suppressor gene. We previously demonstrated that is widely downregulated in various cancers and our in vivo and in vitro analysis revealed as a novel tumor suppressor and regulator of EMT.

The Criterion Validity and Between-Day Reliability of the Perch for Measuring Barbell Velocity During Commonly Used Resistance Training Exercises.

Weakley, J, Munteanu, G, Cowley, N, Johnston, R, Morrison, M, Gardiner, C, Pérez-Castilla, A, and García-Ramos, A. The criterion validity and between-day reliability of the Perch for measuring barbell velocity during commonly used resistance training exercises. J Strength Cond Res 37(4): 787-792, 2023-This study aimed to assess the criterion validity and between-day reliability (accounting for technological and biological variability) of mean and peak concentric velocity from the Perch measurement system.

Design-development of an at-home modular brain-computer interface (BCI) platform in a case study of cervical spinal cord injury.

Objective: The objective of this study was to develop a portable and modular brain-computer interface (BCI) software platform independent of input and output devices. We implemented this platform in a case study of a subject with cervical spinal cord injury (C5 ASIA A).

Background: BCIs can restore independence for individuals with paralysis by using brain signals to control prosthetics or trigger functional electrical stimulation.

A Systematic Review on Fitness Testing in Adult Male Basketball Players: Tests Adopted, Characteristics Reported and Recommendations for Practice.

Background: As basketball match-play requires players to possess a wide range of physical characteristics, many tests have been introduced in the literature to identify talent and quantify fitness in various samples of players. However, a synthesis of the literature to identify the most frequently used tests, outcome variables, and normative values for basketball-related physical characteristics in adult male basketball players is yet to be conducted.

Objective: The primary objectives of this systematic review are to (1) identify tests and outcome variables used to assess physical characteristics in adult male basketball players across all competition levels, (2) report a summary of anthropometric, muscular power, linear speed, change-of-direction speed, agility, strength, anaerobic capacity, and aerobic capacity in adult male basketball players based on playing position and competition level, and (3) introduce a framework outlining recommended testing approaches to quantify physical characteristics in adult male basketball players.

Putting the Squeeze on Compression Garments: Current Evidence and Recommendations for Future Research: A Systematic Scoping Review.

Background: Compression garments are regularly worn during exercise to improve physical performance, mitigate fatigue responses, and enhance recovery. However, evidence for their efficacy is varied and the methodological approaches and outcome measures used within the scientific literature are diverse.

Objectives: The aim of this scoping review is to provide a comprehensive overview of the effects of compression garments on commonly assessed outcome measures in response to exercise, including: performance, biomechanical, neuromuscular, cardiovascular, cardiorespiratory, muscle damage, thermoregulatory, and perceptual responses.

The Validity and Reliability of Commercially Available Resistance Training Monitoring Devices: A Systematic Review.

Background: Monitoring resistance training has a range of unique difficulties due to differences in physical characteristics and capacity between athletes, and the indoor environment in which it often occurs. Traditionally, methods such as volume load have been used, but these have inherent flaws. In recent times, numerous portable and affordable devices have been made available that purport to accurately and reliably measure kinetic and kinematic outputs, potentially offering practitioners a means of measuring resistance training loads with confidence.

Evaluation of epiandrosterone as a long-term marker of testosterone use.

Identification and evaluation of long-term markers is crucial in prolonging the detection window for anabolic steroid abuse in sport. Recently, sulfoconjugated epiandrosterone was identified as a potential long-term marker for the abuse of certain endogenous anabolic agents, including testosterone, which continues to be widely used as a performance enhancing agent in sport. To evaluate the applicability of epiandrosterone sulfate as a marker for testosterone use, administration studies were conducted with multiple modes of testosterone administration - transdermal, intramuscular, and subcutaneous.

Criterion Validity, and Interunit and Between-Day Reliability of the FLEX for Measuring Barbell Velocity During Commonly Used Resistance Training Exercises.

Weakley, J, Chalkley, D, Johnston, R, García-Ramos, A, Townshend, A, Dorrell, H, Pearson, M, Morrison, M, and Cole, M. Criterion validity, and interunit and between-day reliability of the FLEX for measuring barbell velocity during commonly used resistance training exercises. J Strength Cond Res 34(6): 1519-1524, 2020-The aim of this study was to assess the criterion validity, interunit reliability (accounting for technological and biological variance), and between-day reliability of a novel optic laser device (FLEX) for quantifying mean concentric velocity.

Male mice adjust courtship behavior in response to female multimodal signals.

Multimodal signaling is nearly ubiquitous across animal taxa. While much research has focused on male signal production contributing to female mate-choice or preferences, females often give their own multimodal signals during intersexual communication events. Multimodal signal components are often classified based on whether they contain redundant information (e.

Retrospective analysis of a gabapentin high dose taper compared to lorazepam in acute inpatient alcohol withdrawal.

: Benzodiazepines have remained the standard of care for alcohol withdrawal syndrome; however, they have numerous unfavorable physiologic effects. Gabapentin has limited data to support a benefit in reducing benzodiazepine usage in alcohol withdrawal syndrome.: Evaluate the association of an institutional guideline and order set for alcohol withdrawal that incorporates high dose gabapentin tapers in acutely withdrawing patients.

Identifying Candidate Biomarkers for Pleomorphic Adenoma: A Case-Control Study.

Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Kallikrein-related peptidases have been identified as biomarkers in many human tumors and may influence tumor behavior. We investigated KLK1-15 messenger ribonucleic acid and proteins in PA specimens to determine a KLK expression profile for this tumor.

Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with F-GE-180, a Radiotracer for Translocator Protein (TSPO).

Intraplaque inflammation plays an important role in the progression of atherosclerosis. The 18 kDa translocator protein (TSPO) expression is upregulated in activated macrophages, representing a potential target to identify inflamed atherosclerotic plaques. We preclinically evaluated F-GE-180, a novel third-generation TSPO radioligand, in a mouse model of atherosclerosis.

Imaging αβ integrin expression in skeletal metastases with Tc-maraciclatide single-photon emission computed tomography: detection and therapy response assessment.

Purpose: Osteoclast activity is an important factor in the pathogenesis of skeletal metastases and is a potential therapeutic target. This study aimed to determine if selective uptake of Tc-maraciclatide, a radiopharmaceutical targeting αβ integrin, occurs in prostate cancer (PCa) bone metastases and to observe the changes following systemic therapy.

Methods: The study group comprised 17 men with bone-predominant metastatic PCa who underwent whole-body planar and single-photon emission computed tomography/computed tomography (SPECT/CT) imaging with Tc-maraciclatide before (n = 17) and 12 weeks after (n = 11) starting treatment with abiraterone.

Leukopenia Associated with Risperidone Treatment.

Risperidone is an atypical antipsychotic agent that was originally approved by the United States Food and Drug Adminstration for the treatment of schizophrenia. There are many side effects that are frequently associated with the use of risperidone. These include weight gain, anxiety, extra-pyramidal side effects, and elevated prolactin levels.