Publications by authors named "Matthew Manh Nguyen"
Aging (Albany NY)
October 2024
Article Synopsis
- Werner syndrome is linked to mutations in the WRN helicase, which plays a critical role in DNA functions and is associated with premature aging.
- WRN deficiency leads to abnormal levels of constitutive heterochromatin in human fibroblasts, specifically disrupting SATII pericentromeric satellite repeats and affecting protein interactions that organize heterochromatin.
- The study concludes that while WRN loss alters heterochromatin organization independent of senescence, it shares characteristics with changes seen during the aging process.
