Publications by authors named "Matthew Mackeown"
Article Synopsis
- The study focuses on the 5' UTR of the HCoV-OC43 coronavirus and its structural role in influencing viral mechanisms related to pathogenesis.
- By using experimental and computational methods, researchers identified a specific folding structure in the 5' UTR, revealing key features such as stem-loops and coaxial stacking.
- Mutations that disrupted this structure were shown to increase translation efficiency of a reporter gene, demonstrating that the 5' UTR structure actively contributes to the virus's ability to regulate its translation.
