Clinicopathological and Molecular Features of Penile Melanoma With a Proposed Staging System.

Penile melanomas (PM) are an exceedingly rare subtype of mucosal melanoma (MM), and we reviewed the clinicopathologic features and molecular profile in 8 PMs. The patient ages ranged from 46 to 78 (mean: 62.8) years with involvement on the glans (n=5; 62.

Disseminated cryptococcosis with cutaneous manifestation.

Cutaneous cryptococcosis is uncommon. It is usually a result of disseminated infection and can present with a wide variety of skin lesions. We report a case of disseminated cryptococcosis in a kidney transplant recipient who presented with nodular lesions in the forehead following a bout of acute cellular rejection.

Outcomes of primary cutaneous squamous cell carcinoma with perineural invasion: an 11-year cohort study.

Objective: To identify factors associated with poor outcomes in perineurally invasive squamous cell carcinoma.

Design: Retrospective cohort study.

Setting: Two academic hospitals in Boston, Massachusetts.

Primary cutaneous amyloidosis of the external ear: a clinicopathological and immunohistochemical study of 17 cases.

Primary cutaneous amyloidosis includes several forms of localized amyloidosis characterized by superficial amyloid deposits occurring at or near the dermal-epidermal junction in the absence of systemic involvement. Primary cutaneous amyloidosis of the auricular concha and external ear represents a rarely described variant. There have been 27 cases reported in the English language literature, and herein we report 17 additional cases.

Facial nerve hemangiomas: vascular tumors or malformations?

Objective: To reclassify facial nerve hemangiomas in the context of presently accepted vascular lesion nomenclature by examining histology and immunohistochemical markers.

Study Design: Cohort analysis of patients diagnosed with a facial nerve hemangioma between 1990 and 2008.

Setting: Collaborative analysis at a specialty hospital and a major academic hospital.

Juvenile conjunctival nevus: clinicopathologic analysis of 33 cases.

Conjunctival nevi in children and adolescents often have histologic features that can be difficult to differentiate from malignancy. We have identified a subset of childhood nevi displaying a confluent growth pattern and a lack of maturation that we have defined as juvenile conjunctival nevi (JCN), with the aim of further describing the clinicopathologic features of these lesions. Lesions identified as conjunctival nevus in a tertiary referral hospital were reviewed and the subset of lesions identified as JCN were further evaluated.