Spectroscopic and Computational pH Study of Ni and Pd Pyrrole-Imine Chelates with Human Serum Albumin.

Human serum albumin (HSA) efficiently transports drugs in vivo: most are organic. Therefore, it is important to delineate the binding of small molecules to HSA. Here, for the first time, we show that HSA binding depends not only on the identity of the d metal ion, Ni or Pd, of their complexes with bis(pyrrole-imine), HPrPyrr, but on the pH level as well.