Publications by authors named "Matthew L Reimherr"

Article Synopsis
  • * A study on 48 infants examined how DNA methylation patterns in umbilical cord blood and placenta relate to weight measurements at six months, identifying 23 genes from cord blood and 10 from placenta linked to weight outcomes.
  • * Three specific genes (PLIN4, UBE2F, and PPP1R16B) showed strong associations with weight gain, and a new Methylation Risk Score was developed to identify infants at higher risk for obesity, paving the way for more targeted research in the future.
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Childhood obesity represents a significant global health concern and identifying risk factors is crucial for developing intervention programs. Many 'omics' factors associated with the risk of developing obesity have been identified, including genomic, microbiomic, and epigenomic factors. Here, using a sample of 48 infants, we investigated how the methylation profiles in cord blood and placenta at birth were associated with weight outcomes (specifically, conditional weight gain, body mass index, and weight-for-length ratio) at age six months.

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Obesity is a highly heritable condition that affects increasing numbers of adults and, concerningly, of children. However, only a small fraction of its heritability has been attributed to specific genetic variants. These variants are traditionally ascertained from genome-wide association studies (GWAS), which utilize samples with tens or hundreds of thousands of individuals for whom a single summary measurement (e.

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Background: This is the first controlled pharmacologic study in either adults or children with uncomplicated, treatment-resistant attention-deficit/hyperactivity disorder (ADHD). This study augmented stimulant therapy with the atypical antipsychotic brexpiprazole. The Food and Drug Administration preapproved primary outcome measure (Conners' Adult ADHD Rating Scale [CAARS]) showed no drug-placebo differences.

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Background: Metabolomic analysis is commonly used to understand the biological underpinning of diseases such as obesity. However, our knowledge of gut metabolites related to weight outcomes in young children is currently limited.

Objectives: To (1) explore the relationships between metabolites and child weight outcomes, (2) determine the potential effect of covariates (e.

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Our associated paper presented a psychometric evaluation of the Wender Utah Rating Scale (WURS) and its abbreviated version, the WURS-25. Instead of actual factors scores, we employed "item averages" calculated by the average score of each item comprising that factor. We did not present a factor analysis of the WURS-25.

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The Wender Utah Rating Scale (WURS) is a self-report instrument completed by adults assessing a range of childhood symptoms and behaviors consistent with ADHD persisting into adulthood. Many items reflect emotional dysregulation. Although over 30 publications have examined its psychometric properties, reliance on non-clinical samples has limited conclusions from these reports, as have sub-optimal statistical approaches in most previous publications.

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Article Synopsis
  • The study explores the emotional symptoms of adults with ADHD, which aren't fully captured in traditional diagnostic criteria like DSM-5 or ICD-10, using the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS).
  • It analyzes data from eight clinical trials with 1,490 subjects to refine the classification of adult ADHD into two subtypes: ADHD inattentive presentation and ADHD emotional dysregulation presentation.
  • Findings indicate that emotional dysregulation is prevalent and linked to greater severity of ADHD symptoms, suggesting a more effective diagnosis and treatment approach than what current DSM guidelines offer.
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