Publications by authors named "Matthew L McBride"
Article Synopsis
- Nociceptive and pruriceptive neurons in the dorsal root ganglia send pain and itch signals to the spinal cord, with a small subset of these neurons specifically detecting itch-related stimuli like the cytokine IL-31.
- The study reveals that TMEM184B is crucial for the expression of itch receptors and that mice lacking this protein show diminished responses to IL-31 while still reacting normally to pain.
- TMEM184B's influence on pruriceptive neuron development occurs through Wnt signaling pathways, highlighting its role in establishing the diversity of sensations processed by the nervous system.
Inositol monophosphatase 1 as a novel interacting partner of RAGE in pulmonary hypertension.
Am J Physiol Lung Cell Mol Physiol
March 2019
Pulmonary arterial hypertension (PAH) is a lethal disease characterized by progressive pulmonary vascular remodeling. The receptor for advanced glycation end products (RAGE) plays an important role in PAH by promoting proliferation of pulmonary vascular cells. RAGE is also known to mediate activation of Akt signaling, although the particular molecular mechanism remains unknown.
View Article and Find Full Text PDFHemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension.
Am J Respir Cell Mol Biol
September 2018
Although hemolytic anemia-associated pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are more common than the prevalence of idiopathic PAH alone, the role of hemolysis in the development of PAH is poorly characterized. We hypothesized that hemolysis independently contributes to PAH pathogenesis via endothelial barrier dysfunction with resulting perivascular edema and inflammation. Plasma samples from patients with and without PAH (both confirmed by right heart catheterization) were used to measure free hemoglobin (Hb) and its correlation with PAH severity.
View Article and Find Full Text PDF