Non-syndromic OTX2-associated pattern dystrophy: a 10-year multimodal imaging study.

Purpose: To report novel multimodal imaging features and long-term follow-up of Orthodenticle Homeobox 2 (OTX2)-associated pattern Gdystrophy.

Methods: A 14-year-old boy referred with glaucoma suspect and macular pigmentation underwent fundus autofluorescence imaging, optical coherence tomography, fluorescein and indocyanine green angiography, visual field test, microperimetry and electrophysiology over a ten-year period. Next-generation sequencing panel identified a de novo heterozygous likely pathogenic OTX2 variant, c.

Giant pars plana cysts and a diagnostic approach to peripheral retinal elevation with the assistance of multimodal imaging.

A man in his 50s was referred for a suspected superotemporal retinal tear in the right eye. Fundus examination showed multiple areas of elevated retina temporally in both eyes which were immobile and did not reappose with scleral depression. No retinal breaks were present.

Conjunctival amelanotic melanoma presenting as a multifocal pink lesion.

Conjunctival amelanotic malignant melanoma is a rare form of melanoma, which lacks visible pigment and is commonly located underneath the eyelids in the bulbar conjunctiva. In this report, we described a case of a Caucasian women in her 70s who presented with unilateral irritation and tenderness following cataract surgery. On eversion of the eyelid, two elevated pink lesions were noted.

Direct intralesional n-butyl-cyanoacrylate embolization for intractable vertebral hemangioma bleeding: a salvage technique. Illustrative case.

Background: Surgical resection of vertebral hemangiomas in the setting of cord compression can be technically difficult and has the potential for life-threatening hemorrhage. The authors report a case of intraoperative direct intralesional n-butyl-cyanoacrylate embolization for intractable vertebral hemangioma bleeding.

Observations: A 53-year-old woman presented for repeat surgery of a residual vertebral hemangioma after a previous debulking, laminectomy, and fixation that were without problems with bleeding.

Exocomets size distribution in the [Formula: see text] Pictoris planetary system.

The star [Formula: see text] Pictoris harbors a young planetary system of about 20 million years old, which is characterized by the presence of a gaseous and dusty debris disk, at least two massive planets and many minor bodies. For more than thirty years, exocomets transiting the star have been detected using spectroscopy, probing the gaseous part of the cometary comas and tails. The detection of the dusty component of the tails can be performed through photometric observations of the transits.

A wide-orbit giant planet in the high-mass b Centauri binary system.

Planet formation occurs around a wide range of stellar masses and stellar system architectures. An improved understanding of the formation process can be achieved by studying it across the full parameter space, particularly towards the extremes. Earlier studies of planets in close-in orbits around high-mass stars have revealed an increase in giant planet frequency with increasing stellar mass until a turnover point at 1.

The CO-rich atmosphere of a young accreting super-Jupiter.

Isotope abundance ratios have an important role in astronomy and planetary sciences, providing insights into the origin and evolution of the Solar System, interstellar chemistry and stellar nucleosynthesis. In contrast to deuterium/hydrogen ratios, carbon isotope ratios are found to be roughly constant (around 89) in the Solar System, but do vary on galactic scales with a C/C isotopologue ratio of around 68 in the current local interstellar medium. In molecular clouds and protoplanetary disks, CO/CO ratios can be altered by ice and gas partitioning, low-temperature isotopic ion-exchange reactions and isotope-selective photodissociation.

Publisher Correction: A planet within the debris disk around the pre-main-sequence star AU Microscopii.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Impact of time-variant turbulence behavior on prediction for adaptive optics systems.

For high-contrast imaging systems, the time delay is one of the major limiting factors for the performance of the extreme adaptive optics (AO) sub-system and, in turn, the final contrast. The time delay is due to the finite time needed to measure the incoming disturbance and then apply the correction. By predicting the behavior of the atmospheric disturbance over the time delay we can in principle achieve a better AO performance.

The transiting dust clumps in the evolved disc of the Sun-like UXor RZ Psc.

RZ Psc is a young Sun-like star, long associated with the UXor class of variable stars, which is partially or wholly dimmed by dust clumps several times each year. The system has a bright and variable infrared excess, which has been interpreted as evidence that the dimming events are the passage of asteroidal fragments in front of the host star. Here, we present a decade of optical photometry of RZ Psc and take a critical look at the asteroid belt interpretation.

Measuring individuality in habitat use across complex landscapes: approaches, constraints, and implications for assessing resource specialization.

Many mobile marine species are presumed to utilize a broad spectrum of habitats, but this seemingly generalist life history may arise from conspecifics specializing on distinct habitat alternatives to exploit foraging, resting/refuge, or reproductive opportunities. We acoustically tagged 34 red drum, and mapped sand, seagrass, marsh, or oyster (across discrete landscape contexts) use by each uniquely coded individual. Using 144,000 acoustic detections, we recorded differences in habitat use among red drum: proportional use of seagrass habitat ranged from 0 to 100%, and use of oyster-bottom types also varied among fish.

Performance characterization of a broadband vector Apodizing Phase Plate coronagraph.

One of the main challenges for the direct imaging of planets around nearby stars is the suppression of the diffracted halo from the primary star. Coronagraphs are angular filters that suppress this diffracted halo. The Apodizing Phase Plate coronagraph modifies the pupil-plane phase with an anti-symmetric pattern to suppress diffraction over a 180 degree region from 2 to 7 λ/D and achieves a mean raw contrast of 10(-4) in this area, independent of the tip-tilt stability of the system.

Fast & Furious focal-plane wavefront sensing.

We present two complementary algorithms suitable for using focal-plane measurements to control a wavefront corrector with an extremely high-spatial resolution. The algorithms use linear approximations to iteratively minimize the aberrations seen by the focal-plane camera. The first algorithm, Fast & Furious (FF), uses a weak-aberration assumption and pupil symmetries to achieve fast wavefront reconstruction.

Calibrating a high-resolution wavefront corrector with a static focal-plane camera.

We present a method to calibrate a high-resolution wavefront (WF)-correcting device with a single, static camera, located in the focal-plane; no moving of any component is needed. The method is based on a localized diversity and differential optical transfer functions to compute both the phase and amplitude in the pupil plane located upstream of the last imaging optics. An experiment with a spatial light modulator shows that the calibration is sufficient to robustly operate a focal-plane WF sensing algorithm controlling a WF corrector with 40,000 degrees of freedom.

Unintended facilitation between marine consumers generates enhanced mortality for their shared prey.

We manipulated predator densities and prey vulnerability to explore how interactions between two predators affect overall mortality of their shared prey. Our three-member study system included eastern oysters (Crassostrea virginica) and two of its major consumers: southern oyster drills (Stramonita haemastoma) and stone crabs (Menippe adina). Field experiments demonstrated that drills and crabs foraging together generated higher than expected oyster mortality based on each species operating independently, even though crabs also killed some drills.