Development and validation of equations estimating glomerular filtration rates in Chinese patients with type 2 diabetes.

Existing equations to calculate the estimated glomerular filtration rate (eGFR) were derived from nondiabetic Caucasian patients with chronic kidney disease. Here, we developed formulas to more accurately predict the eGFR in Chinese patients with type 2 diabetes and validated their performance in 202 type 2 diabetic and 46 nondiabetic individuals. Within the diabetic cohort, 135 were randomly assigned to a training group, whereas the remaining 67 diabetic and all of the nondiabetic patients were assigned to a validation group.

The renoprotective effects of structured care in a clinical trial setting in type 2 diabetic patients with nephropathy.

Background: The RENAAL Study has confirmed the renoprotective effects of Losartan in type 2 diabetes. In this subgroup analysis from the RENAAL Study, we hypothesized that the intensive care received by patients in a clinical trial setting also reduced the rate of decline in renal function through optimization of all risk factors.

Methods: We compared the rate of deterioration in renal function, expressed as the regression coefficient of the monthly serum creatinine (SeCr) reciprocal (beta-1/Cr) in 55 Chinese type 2 diabetic patients before and after entry into the RENAAL Study.