Background: It has been suggested that cyclosporine A (CsA) induces gingival enlargement by promoting an increase in the gingival extracellular matrix (ECM). Nonetheless, the variable occurrence of CsA-induced gingival enlargement in patients receiving this medication indicates a multifactorial pathogenesis. Clinical observations suggest that local inflammation is associated with the development and severity of CsA-induced gingival enlargement.
View Article and Find Full Text PDFAn important metabolite in nucleotide synthesis, ribose 5-phosphate (R5P) undergoes Maillard reactions at a rate significantly faster than most common sugars and sugar phosphates of its type. At pH = 8 and 37 degrees C, R5P reacts with amino acids to generate UV-absorbing compounds within hours and brownish compounds within a day. The increased rate can be attributed to the strategic location of the 5-phosphate group near the reactive C1 center.
View Article and Find Full Text PDF