Mohs surgery for squamoid eccrine ductal carcinoma.

Squamous eccrine ductal carcinoma is a rare cutaneous malignancy. It has the potential to locally recur and may occasionally metastasize. It presents a diagnostic challenge given its rare nature and overlapping histopathological features with other cutaneous carcinomas.

Early Fractional Ablative Laser for Skin Cancer Excision Scars: A Randomized Split-Scar Study.

Background: Fractional ablative laser resurfacing has been shown to improve the final cosmetic appearance of surgical scars, but optimal timing is unknown.

Objective: To compare surgical scars treated with fractional carbon dioxide (CO 2 ) laser performed on Day 0 and Day 14.

Methods: Prospective, randomized, split-scar, physician-blinded study of 30 surgical scars on the limbs.

Cancer vaccines: the next immunotherapy frontier.

After several decades, therapeutic cancer vaccines now show signs of efficacy and potential to help patients resistant to other standard-of-care immunotherapies, but they have yet to realize their full potential and expand the oncologic armamentarium. Here, we classify cancer vaccines by what is known of the included antigens, which tumors express those antigens and where the antigens colocalize with antigen-presenting cells, thus delineating predefined vaccines (shared or personalized) and anonymous vaccines (ex vivo or in situ). To expedite clinical development, we highlight the need for accurate immune monitoring of early trials to acknowledge failures and advance the most promising vaccines.

Botulinum Toxin for Scalp Dysesthesia.

Scalp dysesthesia is characterized by abnormal cutaneous sensations such as burning, stinging, or itching of the scalp. This condition is particularly challenging to manage as there is a lack of well-established treatments. By limiting release of neurotransmitters such as substance P, glutamate, and calcitonin gene-related peptide, botulinum toxin may have a role in ameliorating neuropathic pain.

Autologous Fat Grafting for Plantar Fasciitis.

Plantar fasciitis is the most common cause of heel pain, accounting for up to 15% of medical foot inquiries. Autologous fat grafting (AFG) is a promising new treatment for plantar fasciitis, whereby the injection of fat may promote a cushioning effect on the heel and reduce plantar pressure, thereby reducing heel pain. We present the case of a patient with chronic plantar fasciitis treated with AFG with significant improvement in foot pain and functional scores.

Buccal Fat Pad Reduction With Intraoperative Fat Transfer to the Temple.

There is now a growing trend for buccal fat pad reduction in patients who desire a decrease in midface and lower face volume, refinement, sculpting, or enhancement of facial features. The buccal fat pad is connected to the temporal fat, and therefore buccal fat pad reduction can result in volume depletion of the temporal fossae. In addition, most patients undergoing this procedure already have pre-existing temporal volume depletion due to aging.

A survey of long-term results with microwave energy device for treating axillary hyperhidrosis.

Microwave energy technology treats axillary hyperhidrosis through thermolysis of the apocrine and eccrine glands. Successful short-term reduction of sweating has been studied, but there is limited information on long-term efficacy and safety. To evaluate patient satisfaction with microwave energy device for axillary hyperhidrosis performed within the last 5 years.

Brief Educational Video Improves Patient Understanding of Mohs Surgery: A Randomized Controlled Trial.

Background: Patient's retention and recall of material discussed in a medical consultation is often inadequate.

Objective: To assess patient's knowledge, anxiety, and understanding of Mohs surgery after viewing a brief educational video.

Method: A prospective, investigator-blinded, randomized controlled trial of 120 consecutive patients before the first Mohs surgery procedure.

Intraoperative Electrosurgical Depilation of a Skin Graft.

Full-thickness skin grafts harvested from hair-bearing areas may negatively impact cosmetic outcomes if the recipient site is hairless. Intraoperative depilation of unwanted hair follicles using an electrosurgical device can permanently remove hair with a single treatment and improve overall cosmesis.

Basal cell nevus syndrome: From DNA to therapeutics.

Basal cell nevus syndrome, also known as Gorlin syndrome, is a hereditary cancer syndrome associated with multiple basal cell carcinomas, congenital defects, and nondermatologic tumors. This disease is autosomal dominant with variable expressivity and is caused by abnormalities in the sonic hedgehog signaling pathway. Management requires a multidisciplinary approach and should include the biopsychosocial needs of patients and their families.

Botulinum Toxin for Paramedian Interpolated Forehead Flaps.

The forehead skin closely resembles the texture and color of the midface region. As such, the use of a paramedian forehead flap to repair a midface defect provides optimal cosmesis; however, the donor forehead site may be left with an undesirable scar in a highly visible region of the face. Cutaneous surgeons possess a variety of traditional techniques intended to minimize scarring.

The effect of platelet-rich plasma on female androgenetic alopecia: A randomized controlled trial.

Background: Platelet-rich plasma (PRP) may be a useful treatment for androgenetic alopecia (AGA), although objective studies are needed.

Objective: To determine whether PRP injections improve female AGA.

Method: Prospective randomized controlled trial of 30 women diagnosed with AGA.

Antibiotic Practices in Mohs Micrographic Surgery.

Background: Mohs micrographic surgery is a safe procedure with low rates of infection.

Objective: To establish current antibiotic prescribing practices amongst Mohs surgeons.

Methods And Materials: 16-question survey sent to American College of Mohs Surgery members.

The Impact of Submental Deoxycholic Acid Injections on Neck Surgery.

Non-invasive procedures targeting the submental fat or “double chin” have undergone a surge in popularity. Injections of deoxycholic acid, a secondary bile acid, have recently received FDA-approval for fat reduction in this area. With appropriate patient selection, this preparation of 10 mg/mL of sodium deoxycholate (Kybella®, Kythera Biopharmaceuticals, Westlake Village, CA) leads to aesthetic improvement of moderate-to-severe convexity or fullness associated with submental fat in adults.

Methacrylate Polymer Powder Dressing for a Nasal Surgical Defect.

The fusion of technology and medicine has led to the advent of advanced wound healing techniques that may be adapted to the management of surgical defects. Shortened duration of healing and ease-of-use are two potential benefits under investigation. Here we describe a 65-year-old male with a nasal alar wound that was allowed to heal with secondary intention, assisted by a novel methacrylate polymer powder dressing.