Publications by authors named "Matthew J Ott"
Article Synopsis
- Researchers created a new analysis tool to enhance the detection of nitric oxide (NO) levels in immune cells from melanoma patients during clinical trials involving ipilimumab and peptide vaccines.
- This tool helps visualize immune cell phenotypes without needing complex clustering methods and links them to patient outcomes like relapse-free survival (RFS).
- The study revealed that NO plays a dual role in melanoma, with levels found in both immune-suppressing cells (linked to shorter RFS) and immune-stimulating cells (associated with longer RFS), highlighting NO's complex immunomodulatory effects.
