Complex intra-operonic dynamics mediated by a small RNA in Streptomyces coelicolor.

Streptomyces are predominantly soil-dwelling bacteria that are best known for their multicellular life cycle and their prodigious metabolic capabilities. They are also renowned for their regulatory capacity and flexibility, with each species encoding >60 sigma factors, a multitude of transcription factors, and an increasing number of small regulatory RNAs. Here, we describe our characterization of a conserved small RNA (sRNA), scr4677.

Comparative analysis of non-coding RNAs in the antibiotic-producing Streptomyces bacteria.

Background: Non-coding RNAs (ncRNAs) are key regulatory elements that control a wide range of cellular processes in all bacteria in which they have been studied. Taking advantage of recent technological innovations, we set out to fully explore the ncRNA potential of the multicellular, antibiotic-producing Streptomyces bacteria.

Results: Using a comparative RNA sequencing analysis of three divergent model streptomycetes (S.