The low-energy conformations of gonadotropin-releasing hormone in aqueous solution.

Using the chain-build-up method based on Empirical Conformational Energies of Peptides Program including solvation, we have computed, the low energy conformations of gonadotrpin-releasing hormone, GnRH, whose sequence is Pyro-Glu(PG)-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. We have found 5,077 solvated conformations with conformational energies that were within 5 kcal/mole of that of the global minimum. These minima were found to occur in 802 distinct conformational classes of which 25 represented 70 % of the Boltzmann energy-weighted structures.

Clear Tinnitus, middle-ear pressure, and tinnitus relief: a prospective trial.

Goal: Our goal was to establish the efficacy, in a 12-week period, of Clear Tinnitus for tinnitus relief in patients with tinnitus of the severe, disabling type.

Hypothesis: We hypothesized that tinnitus relief with Clear Tinnitus reflects improvement in the sensory component of the tinnitus complaint by controlling the factor of aeration of the middle ears and improving eustachian tube function.

Method: In a prospective clinical trial of a homeopathic preparation--Clear Tinnitus--we attempted to identify in 15 tinnitus patients (14 male, 1 female; mean age, 47.

Quantitative electroencephalography power analysis in subjective idiopathic tinnitus patients: a clinical paradigm shift in the understanding of tinnitus, an electrophysiological correlate.

Unlabelled: We report a descriptive analysis-interpretation of quantitative electroencephalography (QEEG) data for the metric of power in patients with tinnitus of the severe disabling type (N = 61). The results are based on a statistical analysis of the data compared to a normative database as calculated in Z scores, controlling for the factors of age, gender, IQ, and the like.

Method: We analyzed the QEEG data for the metric of power to measure (1) the number of significant recordings, normal and abnormal; (2) the significant recordings by electrode recording sites; (3) distribution of the electroencephalographic (EEG) frequency bands; and (4) occurrence of the EEG frequency bands correlated with the electrode recording sites.

Ultra-high-frequency acoustic stimulation and tinnitus control: a positron emission tomography study.

Ultra-high-frequency (UHF) external acoustic stimulation with the UltraQuiet device (UQ) has been reported to provide significant relief of severe disabling-type tinnitus. The nuclear medicine imaging technique of positron emission tomography (PET) was selected as a monitoring system to compare objectively metabolic alterations in brain function before and after UHF/UQ and to correlate the PET data with the subjective behavioral response of patients reporting tinnitus relief. PET of brain was completed on 6 patients randomly selected from a cohort of 15 patients included in a protocol to establish long-term tinnitus relief with UHF/UQ.