Publications by authors named "Matthew Illsley"

In this study, we developed a method to prepare inorganic nanoparticles in situ on the surface of cationized cellulose using a rapid microwave-assisted synthesis. Selenium nanoparticles (SeNPs) were employed as a novel type of antimicrobial agent and, using the same method, silver nanoparticles (AgNPs) were also prepared. The results demonstrated that both SeNPs and AgNPs of about 100 nm in size were generated on the cationized cellulose fabrics.

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The process of wound healing is often accompanied by bacterial infection or critical colonization, resulting in protracted inflammation, delayed reepithelization, and production of pungent odors. The malodor produced by these wounds may lower health-related quality of life and produce psychological discomfort and social isolation. Current management focuses on reducing bacterial activity within the wound site and absorbing malodorous gases.

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Article Synopsis
  • - Werner's syndrome (WS) is a genetic disorder that leads to premature aging, primarily studied through WS fibroblasts, which exhibit faster aging due to specific cellular issues like telomere shortening and halted DNA replication.
  • - Unlike WS fibroblasts, human dermal keratinocytes (skin cells) from WS patients can proliferate extensively (over 100 population doublings) while still maintaining mechanisms that regulate growth, indicating they don't show signs of premature senescence.
  • - The study suggests that certain tissues, like the epidermis, remain unaffected by WS-related aging symptoms, supporting the idea that Werner's syndrome is a form of segmental progeroid syndrome, affecting some cell types differently than others.
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The purpose of this work was proof of concept to develop a novel, cost effective protocol for the binding of bacteriophages to a surface without loss of function, after storage in various media. The technology platform involved covalently bonding bacteriophage 13 (a Pseudomonas aeruginosa bacteriophage) to two magnetised multiwalled carbon nanotube scaffolds using a series of buffers; bacteriophage-nanotube (B-N) conjugates were efficacious after storage at 20 °C for six weeks. B-N conjugates were added to human cell culture in vitro for 9 days without causing necrosis and apoptosis.

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