Improving the exchange and correlation potential in density-functional approximations through constraints.

We review and expand on our work to impose constraints on the effective Kohn-Sham (KS) potential of local and semi-local density-functional approximations. Constraining the minimisation of the approximate total energy density-functional invariably leads to an optimised effective potential (OEP) equation, the solution of which yields the KS potential. We review briefly our previous work on this and demonstrate with numerous examples that despite the well-known mathematical issues of the OEP with finite basis sets, our OEP equations are numerically robust.

Systematic review of neurotrophic tropomyosin-related kinase inhibition as a tumor-agnostic management strategy.

To conduct a systematic review and meta-analysis feasibility of clinical, quality of life and economic evidence for neurotrophic tropomyosin-related receptor tyrosine kinases () inhibitors in patients with gene fusion-positive tumors. Databases were searched for studies on inhibitors in adult and pediatric patients. 27 publications reported clinical data for seven interventions.

Patient selection for anti-PD-1/PD-L1 therapy in advanced non-small-cell lung cancer: implications for clinical practice.

Immune checkpoint inhibitors targeting PD-1 or PD-L1 represent a standard treatment option for patients with advanced non-small-cell lung cancer. However, a substantial proportion of patients will not benefit from these treatments, and robust biomarkers are required to help clinicians select patients who are most likely to benefit. Here, we discuss the available evidence on the utility of clinical characteristics in the selection of patients with advanced non-small-cell lung cancer as potential candidates for single-agent anti-PD-1/PD-L1 therapy, and provide practical guidance to clinicians on identifying those patients who are most likely to benefit.

Extracellular Matrix from Whole Porcine Heart Decellularization for Cardiac Tissue Engineering.

Decellularization of whole porcine hearts followed by recellularization with fully differentiated cells made from patient-specific human induced pluripotent stem cells (iPSCs) may provide the ultimate solution for patients with heart failure. Decellularization is the process of completely disrupting all cells and removing the cellular components (e.g.

Spin Relaxation in GaAs: Importance of Electron-Electron Interactions.

We study spin relaxation in n-type bulk GaAs, due to the Dyakonov-Perel mechanism, using ensemble Monte Carlo methods. Our results confirm that spin relaxation time increases with the electronic density in the regime of moderate electronic concentrations and high temperature. We show that the electron-electron scattering in the non-degenerate regime significantly slows down spin relaxation.

Postactivation potentiation of force is independent of h-reflex excitability.

Unlabelled: The contractile history of muscle can potentiate electrically evoked force production. A link to voluntary force production, related in part to an increase in reflex excitability, has been suggested.

Purpose: Our purpose was to quantify the effect of postactivation potentiation on voluntary force production and spinal H-reflex excitability during explosive plantar flexion actions.

The application of postactivation potentiation to elite sport.

Recently there has been considerable interest and research into the functional significance of postactivation potentiation (PAP) on sport performance. The interest has evolved around the potential for enhancing acute performance or the long-term training effect, typically in the form of complex training. Complex training usually involves performing a weight-training exercise with high loads before executing a plyometric exercise with similar biomechanical demands.