Publications by authors named "Matthew H Gnirke"
Article Synopsis
- The study examines white matter microstructure in young adults with 22q11.2 deletion syndrome (22q11.2DS) using diffusion tensor imaging (DTI), focusing on the cingulum bundle (CB), which is linked to schizophrenia and psychotic symptoms.
- Findings reveal significant alterations in white matter metrics of the CB in 22q11.2DS individuals compared to controls, and these changes are associated with positive prodromal symptoms of psychosis.
- The results suggest that antipsychotic and mood stabilizer medications may improve white matter microstructure, indicating a potential role for medication in the management of neuroanatomic disruptions in 22q11.2DS, independent of psychotic symptoms.
Article Synopsis
- - The study used diffusion tensor imaging (DTI) to investigate white matter structures in the brains of individuals with 22q11.2 deletion syndrome (22q11.2DS) and control subjects, focusing on tracts previously linked to schizophrenia.
- - Findings showed significant differences in white matter metrics among groups, with reductions in specific tracts (anterior limb of the internal capsule, fornix, uncinate fasciculus) in those with 22q11.2DS correlating with early signs of psychosis and genetic variations in the Nogo-66 receptor gene.
- - The research suggests that abnormalities in these brain structures may contribute to the development of psychosis, indicating that the Nogo-66 receptor
Velo-cardio-facial syndrome (VCFS) is caused by a micro-deletion of over 40 genes at the q11.2 locus of chromosome 22 and is a risk factor for the development of schizophrenia and other psychiatric disorders. COMT, one of the genes located in the deleted region, has been considered as a major candidate gene for genetic susceptibility in psychiatric diseases.
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