Publications by authors named "Matthew H Baer"
Stress granules (SGs) are large ribonucleoprotein assemblies that form in response to acute stress in eukaryotes. SG formation is thought to be initiated by liquid-liquid phase separation (LLPS) of key proteins and RNA. These molecules serve as a scaffold for recruitment of client molecules.
View Article and Find Full Text PDFArticle Synopsis
- Mutations in proteins associated with stress granules are linked to neurodegenerative diseases, particularly in their prion-like domains (PrLDs).
- Researchers found that various yeast PrLDs can form visible aggregates in response to stress, showing specific sequence features that influence their localization to stress granules.
- A prediction method based on the composition of PrLDs was developed, revealing that amino acid composition largely guides recruitment to stress granules, while the exact sequence is less important.