Publications by authors named "Matthew Gerace"
Article Synopsis
- Clozapine is underused due to clinicians' lack of knowledge and concerns about its adverse drug effects (ADEs), leading to reluctance in treatment.
- This systematic review analyzed 305 reports, ultimately summarizing 152 relevant studies on clozapine ADEs, revealing that most occur within the first 6 months after starting the medication.
- The review found that while many ADEs subside with dose adjustments, serious conditions like myocarditis and agranulocytosis should not be re-challenged, and high plasma levels of clozapine can increase the likelihood of certain ADEs.
Hemostasis and thrombosis are now increasingly recognized as integrally related to blood rheology and blood flow. Platelets, for example, are known to access the vessel wall in ways which depend upon the small-scale motions of neighboring erythrocytes, and access one another via collisions driven by gradients in blood flow velocity. In this context, flow devices have become a subject of great interest in the clinical assessment of bleeding disorders, especially platelet function defects and von Willebrand disease.
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