Background: Multi-tracer PET/SPECT imaging enables different modality tracers to be present simultaneously, allowing multiple physiological processes to be imaged in the same subject, within a short time-frame. Fluorine-18 and technetium-99m, two commonly used PET and SPECT radionuclides, respectively, possess different emission profiles, offering the potential for imaging one in the presence of the other. However, the impact of the presence of each radionuclide on scanning the other could be significant and lead to confounding results.
View Article and Find Full Text PDFPositron Emission Tomography (PET) imaging with antibody-based contrast agents frequently uses the radioisotopes [Cu]Cu and [Zr]Zr. The macrobicyclic chelator commonly known as sarcophagine (sar) is ideal for labeling receptor-targeted biomolecules with [Cu]Cu. The siderophore chelator, desferrioxamine-B (dfo), has been widely used to incorporate [Zr]Zr into antibodies.
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