Publications by authors named "Matthew E Weno"
Article Synopsis
- - T cell-mediated destruction of insulin-producing islets is a key feature of autoimmune diabetes, and this study focused on the behavior of CD4 T cells reacting to insulin-derived peptides in NOD mice during diabetes onset.
- - Using single-cell RNA sequencing, researchers found that T cells specific to islet antigens varied greatly in their development and needed XCR1 dendritic cells for activation, with varying effector profiles among different epitope-specific T cells.
- - Notably, CD4 T cells responsive to hybrid-insulin C-chromogranin A were found to be pathogenic, and targeting these cells with specific antibodies prevented diabetes, suggesting potential for targeted therapies in treating autoimmune diabetes.
Adoptive immunotherapy with Tregs is a promising approach for preventing or treating type 1 diabetes. Islet antigen-specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical application. To generate Tregs that recognize islet antigens, we engineered a chimeric antigen receptor (CAR) derived from a monoclonal antibody with specificity for the insulin B chain 10-23 peptide presented in the context of the IAg7 MHC class II allele present in NOD mice.
View Article and Find Full Text PDFUnlabelled: Adoptive immunotherapy with Tregs is a promising approach for prevention or treatment of type 1 diabetes. Islet antigen-specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical application. To generate Tregs that recognize islet antigens, we engineered a chimeric antigen receptor (CAR) derived from a monoclonal antibody with specificity for the insulin B-chain 10-23 peptide presented in the context of the IA MHC class II allele present in NOD mice.
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