Identification of a hemerythrin-like domain in a P1B-type transport ATPase.

The P(1B)-type ATPases couple the energy of ATP hydrolysis to metal ion translocation across cell membranes. Important for prokaryotic metal resistance and essential metal distribution in eukaryotes, P(1B)-ATPases are divided into subclasses on the basis of their metal substrate specificities. Sequence analysis of putative P(1B-5)-ATPases, for which the substrate has not been identified, led to the discovery of a C-terminal soluble domain homologous to hemerythrin (Hr) proteins and domains.