Publications by authors named "Matthew E Battaglia"
We present genetic analyses of murine weight loss during dietary restriction (DR) for females eating 60% ad libitum (AL). We examined 5 cohorts across 81 different strains (22 strains tested twice) that included the LXS and LSXSS recombinant inbred strains, the LXS parental strains ILS and ISS, and the classical inbreds 129S6, A, BALB/c, C57BL/6, C3H, and DBA. Weight loss exhibited highly significant genetic variation, with DR body weights ranging from approximately 60 to approximately 85% of AL body weight.
View Article and Find Full Text PDFQuantitative trait Loci specifying the response of body temperature to dietary restriction.
J Gerontol A Biol Sci Med Sci
February 2004
Article Synopsis
- Dietary restriction (DR) has been shown to slow down aging and increase lifespan in various species, with a notable impact on reducing body temperature in homeotherms like mice.
- A study conducted on genetically diverse mice revealed that about 35% of the variation in body temperature response to DR is influenced by genetics, with specific genetic regions identified on chromosomes 9 and 17.
- These findings suggest that the identified genetic factors could help further investigate how body temperature responses to DR might relate to life extension, and offer a pathway for discovering the underlying genes through positional cloning.
Article Synopsis
- - Dietary restriction (DR) can slow aging and increase lifespan in mammals by lowering body temperature (T(b)), suggesting T(b) could be linked to the benefits of DR.
- - A study on 28 strains of female mice found significant differences in T(b) responses to DR, with variations from 1.5 to 5 degrees Celsius below normal.
- - The observed T(b) variations were not connected to factors like thermoregulation or food intake, indicating potential for further research on the relationship between T(b) and life extension during DR.