Publications by authors named "Matthew D Tobelmann"
Expanded CAG diseases are progressive neurodegenerative disorders in which specific proteins have an unusually long polyglutamine stretch. Although these proteins share no other sequence or structural homologies, they all aggregate into intracellular inclusions that are believed to be pathological. We sought to determine what impact the position and number of glutamines have on the structure and aggregation of the host protein, apomyoglobin.
View Article and Find Full Text PDFA strategy for generating polyglutamine 'length libraries' in model host proteins.
Protein Eng Des Sel
March 2008
Article Synopsis
- Huntington's disease is a neurodegenerative condition linked to proteins with an extended polyglutamine (polyQ) sequence, with a critical length threshold for disease development.
- The specific proteins involved in each of the nine known diseases are distinct in their characteristics, and the length of the polyQ region influences protein misfolding and aggregation.
- The research developed a method to create libraries of polyQ proteins with varying lengths and positions, allowing for in-depth exploration of how these factors relate to protein misfolding and contributing to disease.