Publications by authors named "Matthew D Perricone"

Article Synopsis
  • Pancreatic cancer is highly lethal and involves complex changes in the tumor microenvironment and metabolism, which researchers aimed to understand using single-cell RNA-sequencing from human pancreas samples.
  • The study found that cancer cells showed increased biosynthesis, while immune cells displayed a downregulation of mitochondrial functions, indicating specific metabolic alterations among different cell types.
  • Researchers also discovered that tumor-associated macrophages (TAMs) might supply cholesterol to cancer cells, suggesting a possible new mechanism for cancer growth and a potential target for future therapies.
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The liver is a functionally unique organ with an immunosuppressive microenvironment. The liver is the sixth most common site of primary cancer in humans and is a frequent site of metastasis from other solid tumors. The development of effective therapies for primary and metastatic liver cancer has been challenging due to the complex metabolic and immune microenvironment of the liver.

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