Publications by authors named "Matthew D Norton"
Article Synopsis
- * The study explored whether A. baumannii has a DNA damage response similar to Escherichia coli and found that specific genes are activated upon DNA damage, indicating a different regulatory mechanism for A. baumannii.
- * The research revealed that A. baumannii’s ability to acquire antibiotic resistance, like rifampin resistance, is linked to an increase in specific DNA polymerase genes in response to damage, suggesting its ability to mutate under stress conditions may lead to greater resistance in clinical environments.
DinB (DNA Pol IV) is a translesion (TLS) DNA polymerase, which inserts a nucleotide opposite an otherwise replication-stalling N(2)-dG lesion in vitro, and confers resistance to nitrofurazone (NFZ), a compound that forms these lesions in vivo. DinB is also known to be part of the cellular response to alkylation DNA damage. Yet it is not known if DinB active site residues, in addition to aminoacids involved in DNA synthesis, are critical in alkylation lesion bypass.
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