Publications by authors named "Matthew D Kutyna"
Article Synopsis
- Sudden cardiac death (SCD) without an explanation is linked to genetic factors, but the relationship between specific genetic variants and unexplained SCD in White and African American adults has not been thoroughly studied before.
- A study involving 683 participants (413 with sequenced DNA) examined the frequency of pathogenic or likely pathogenic (P/LP) variants in genes related to inherited cardiomyopathies and arrhythmia syndromes among those who died from unexplained SCD.
- The results revealed that 18.4% of participants carried P/LP variants; predominantly, these were linked to hypertrophic cardiomyopathy, dilated cardiomyopathy, and long QT syndrome, highlighting a significant connection between genetic risk factors and unexpl
Article Synopsis
- Coronary artery disease is a major health issue that significantly contributes to illness and death, with factors like intraplaque hemorrhage playing a key role in plaque development.
- The study focuses on establishing a method to assess the permeability of microvessels in fresh human coronary artery samples using the Evans Blue Dye assay, which had not been previously done.
- The protocol includes steps for perfusion of arteries, sample collection for analysis, and optional use of a mouse model to further investigate vascular permeability in different health conditions.
Objective- Drug-eluting stents eluting canonical mTOR (mammalian target of rapamycin) inhibitors are widely used to treat coronary artery disease but accelerate the development of atherosclerosis within the stent (neoatherosclerosis)-a leading cause of late stent failure. We recently showed that canonical mTOR inhibitors bind FKBP12.6 (12.
View Article and Find Full Text PDFIntake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non-foam cell antiinflammatory macrophage phenotype that was previously considered atheroprotective. Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic samples, cultured cells, and a mouse model of advanced atherosclerosis, we investigated the role of intraplaque hemorrhage on macrophage function with respect to angiogenesis, vascular permeability, inflammation, and plaque progression.
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