Publications by authors named "Matthew D Bramble"
Article Synopsis
- The research focuses on the female reproductive system's diversity and function among tetrapods, highlighting challenges in comparing species due to unique adaptations.
- Using the brown anole (Anolis sagrei), the study analyzes gene expression across three regions of the reproductive tract through RNA-sequencing, identifying thousands of differentially expressed genes.
- The findings provide insights into shared and unique gene expression patterns, including a consistent Hox gene expression in mammals, and establish a foundation for future studies on reproductive organ function and evolution in tetrapods.
Article Synopsis
- The CDCA7 protein, involved in ICF syndrome, has a unique carboxyl-terminal cysteine-rich domain (CRD) that binds to a specific DNA structure.
- This binding occurs preferentially with a hemi-methylated non-B DNA form, distinguishing CDCA7 from ICF mutants.
- CDCA7's concentration in specific chromatin regions during DNA replication suggests it plays a crucial role in directing DNA methylation at juxtacentromeric regions.
, encoding a protein with a C-terminal cysteine-rich domain (CRD), is mutated in immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome, a disease related to hypomethylation of juxtacentromeric satellite DNA. How CDCA7 directs DNA methylation to juxtacentromeric regions is unknown. Here, we show that the CDCA7 CRD adopts a unique zinc-binding structure that recognizes a CpG dyad in a non-B DNA formed by two sequence motifs.
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