Electromyographic Responses Across Different Pulse-Widths of Sacral Neuromodulation in Sheep.

Objectives: In rodents, we reported that short pulse-width (PW) neuromodulation might provide more efficient therapy delivery than traditional 0.21 msec PW. Using fully implanted, commercialized systems in the sheep, the goal of this study was to characterize the relationship of electromyographic (EMG) responses of the external anal sphincter (EAS) to different PWs of sacral neuromodulation (SNM).

Comparison of Active Stimulating Electrodes of Sacral Neuromodulation.

Objective: The goal of this study was to compare the motor response to sacral neuromodulation (SNM) with different pairs of stimulating electrodes in anesthetized and awake sheep.

Materials And Methods: Similar to SNM clinical use in humans, the InterStim quadripolar tined lead was implanted adjacent to the S3 nerve root in sheep and bipolar stimulation was configured with one electrode negative and one electrode positive on the four contacts (0 most distal to device, 1, 2, and 3 most proximal).

Results: Electrode 3-cathode and electrode 0-anode (3-/0+) stimulation had the lowest visual response threshold (0.