Publications by authors named "Matthew Culver"
Characterization of Decellularized Plant Leaf as an Emerging Biomaterial Platform.
ACS Biomater Sci Eng
October 2024
Article Synopsis
- Decellularized plants, particularly monocot leaves, show promise as biomaterials for cell culture and tissue engineering due to their unique biochemical, mechanical, and structural properties.
- The study utilized alkali treatment to effectively remove DNA and proteins, with quantitative analysis revealing changes in cellulose, hemicellulose, and lignin content.
- Mechanical tests highlighted variations in strength based on species and decellularization, while imaging showed microgrooves on the leaves, indicating potential for water uptake but limited biomolecule transport; the leaves were also minimally toxic to mammalian cells when degraded with enzymes.
Noncritical aortic coarctation (COA) typically presents beyond early childhood with hypertension. Correction of COA does not ensure a return to normal cardiovascular health, but the mechanisms are poorly understood. Therefore, we developed a porcine COA model to study the secondary cardiovascular changes.
View Article and Find Full Text PDFCell migration is important during early animal embryogenesis. Cell migration and cell shape are controlled by actin assembly and dynamics, which depend on capping proteins, including the barbed-end heterodimeric actin capping protein (CP). CP activity can be regulated by capping-protein-interacting (CPI) motif proteins, including CARMIL (capping protein Arp2/3 myosin-I linker) family proteins.
View Article and Find Full Text PDF