Publications by authors named "Matthew C Mannino"
Article Synopsis
- Liquid biopsies offer a noninvasive way to study treatment response and resistance in metastatic renal cell carcinoma (mRCC), focusing on circulating tumor cells (CTCs) instead of traditional tissue biopsies.
- Researchers analyzed 457 liquid biopsies from 104 mRCC patients, assessing CTC numbers and the HLA I to PD-L1 ratio, discovering that lower CTC counts correlated with better treatment responses and longer survival.
- The study highlights the significance of monitoring CTC counts and the HP ratio as potential biomarkers for predicting and tracking responses to immunotherapy in mRCC patients.
Although therapeutic options for patients with advanced renal cell carcinoma (RCC) have increased in the past decade, no biomarkers are yet available for patient stratification or evaluation of therapy resistance. Given the dynamic and heterogeneous nature of clear cell RCC (ccRCC), tumor biopsies provide limited clinical utility, but liquid biopsies could overcome these limitations. Prior liquid biopsy approaches have lacked clinically relevant detection rates for patients with ccRCC.
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