Pharmacokinetics, metabolism, and efficacy of the antimalarial natural product bromophycolide A.

A suite of pharmacokinetic and pharmacological studies show that bromophycolide A (), an inhibitor of drug-sensitive and drug-resistant , displays a typical small molecule profile with low toxicity and good bioavailability. Despite susceptibility to liver metabolism and a short half-life, significantly decreased parasitemia in a malaria mouse model. Combining these data with prior SAR analyses, we demonstrate the potential for future development of and its bioactive ester analogs.