Burial of nonpolar surface area and thermodynamic stabilization of globins as a function of chain elongation.

Proteins are biosynthesized from N to C terminus before they depart from the ribosome and reach their bioactive state in the cell. At present, very little is known about the evolution of conformation and the free energy of the nascent protein with chain elongation. These parameters critically affect the extent of folding during ribosome-assisted biosynthesis.

Climate change and health in the urban environment: adaptation opportunities in Australian cities.

Urban populations are growing rapidly throughout the Asia-Pacific region. Cities are vulnerable to the health impacts of climate change because of their concentration of people and infrastructure, the physical (geographical, material, and structural) attributes of the built environment, and the ecological interdependence with the urban ecosystem. Australia is one of the most highly urbanized countries in the region and its already variable climate is set to become hotter and drier with climate change.

A social-ecological perspective on health in urban environments.

Human health in our cities is an expression of complex social and environmental interactions not previously faced in our long evolutionary history. In this paper, we present a social-ecological perspective on the complex nature of emerging public health problems in cities and identify some of the research questions emerging from this new view of the city. We argue that an integrative urban science agenda is needed not only to inform urban policy, planning and design, but also to alert people to the consequences of and trade-offs around their choices and behaviours.