Publications by authors named "Matthew Bartock"
Article Synopsis
- The study investigates the effects of post-transplant cyclophosphamide (PTCy) on immune reconstitution in patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), focusing on T cell function and composition.
- Results showed that PTCy significantly delayed T cell reconstitution, increasing regulatory T cells (Tregs) while decreasing naïve T cells, leading to a distinct immune signature compared to those who did not receive PTCy.
- The research also found that the presence of multiple inhibitory receptors on T cells and the persistence of PD-1 on CD8 T cells correlated with worse clinical outcomes, such as disease relapse and graft-versus-host disease (GVHD).
