Late recognition of an early catastrophic failure of a carbon fiber reinforced distal femoral plate: A case report.

The use of carbon fiber reinforced implants to address distal femur fractures has gained in popularity due to their favorable mechanical characteristics and potential for improved healing. The failure of metal locked plates for this application has been widely reported. Here is presented a novel case of early failure of a carbon fiber reinforced polyetheretherketone (PEEK) plate applied for a distal femur fracture.

Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes.

In sensitized individuals birch pollen induces an allergic response characterized by IgE-dependent mast cell degranulation of mediators, such as alpha-chymase and other serine proteases. In birch and other plant pollens, a major allergen is profilin. In mammals, profilin homologues are found in an intracellular form bound to cytoskeletal or cytosolic proteins or in a secreted form that may initiate signal transduction.