J Renin Angiotensin Aldosterone Syst
September 2023
Objective: We tested the hypothesis that postpartum combined oral contraceptive (COC) treatment would induce oxidative stress via the adenosine deaminase-xanthine oxidase pathway in the kidney. We also sought to determine whether mineralocorticoid receptor (MR) or glucocorticoid receptor (GR ) blockade would suppress the activities of ADA and xanthine oxidase caused by postpartum COC treatment in the kidney.
Methods: Twenty-four Wistar dams were randomly assigned to 4 groups ( = 6/group).