Chromatographic editing enhances natural product discovery.

Fungi are known for their diverse biologically active secondary metabolites, compounds that have provided the basis for many landmark therapeutics in the last century. Due to ease of collection and culturing, the existing fungal chemical literature is vast, and fungal natural product isolation can often be hindered by the numerous nuisance and pan-toxic compounds that many strains produce. Dereplication efforts, aimed at identifying such compounds early in the purification, are imperative to reduce time and expense of rediscovery of known metabolites.

Friomaramide, a Highly Modified Linear Hexapeptide from an Antarctic Sponge, Inhibits Liver-Stage Development.

The cold waters of Antarctica are known to harbor a rich biodiversity. Our continuing interest in the chemical analysis of Antarctic invertebrates has resulted in the isolation of friomaramide (), a new, highly modified hexapeptide, from the Antarctic sponge . The structure of friomaramide was determined using spectroscopic methods and its configuration established by Marfey's method.