Trends in hospitalization and factors associated with in-hospital death among pediatric admissions with implantable cardioverter defibrillators.

Background: As pediatric implantable cardioverter-defibrillator (ICD) utilization increases, hospital admission rates will increase. Data regarding hospitalizations among pediatric patients with ICDs are lacking. In addition, hospital mortality rates are unknown.

Ultrafast Spectroscopic Dynamics of Quinacrine-Riboflavin Binding Protein Interactions.

Redox active cofactors play a dynamic role inside protein binding active sites because the amino acids responsible for binding participate in electron transfer (ET) reactions. Here, we use femtosecond transient absorption (FsTA) spectroscopy to examine the ultrafast ET between quinacrine (Qc), an antimalarial drug with potential anticancer activity, and riboflavin binding protein (RfBP) with a known K = 264 nM. Steady-state absorption reveals a ∼ 10 nm red-shift in the ground state when QcH is titrated with RfBP, and a Stern-Volmer analysis shows ∼84% quenching and a blue-shift of the QcH photoluminescence to form a 1:1 binding ratio of the QcH-RfBP complex.