Publications by authors named "Matthew A Cooley"
Article Synopsis
- This systematic review and meta-analysis evaluates the effectiveness of UroVysion FISH testing in detecting pancreaticobiliary malignancy by analyzing various definitions of a positive result from different studies.
- The review included data from 18 studies with a total of 2,516 FISH specimens, identifying 1,133 cases (45.0%) of malignancy, while reporting an overall sensitivity of 57.6% and specificity of 87.8% across studied definitions.
- Results indicated that using polysomy alone as a positive threshold provided high specificity (96.2%) but lower sensitivity (49.4%), whereas combining polysomy with tetrasomy/trisomy improved sensitivity to 64.3% but reduced specificity
Background And Aims: Early identification of malignant biliary strictures (MBSs) is challenging, with up to 20% classified as indeterminants after preliminary testing and tissue sampling with endoscopic retrograde cholangiopancreatography. We aimed to evaluate the use of methylated DNA markers (MDMs) from biliary brushings to enhance MBS detection in a prospective cohort.
Approach: Candidate MDMs were evaluated for their utility in MBS diagnosis through a series of discovery and validation phases.
Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly associated with immune-mediated disorders. In this study, we implemented multitrait joint analyses to genome-wide association summary statistics of PSC and numerous clinical and epidemiological traits to estimate the genetic contribution of each trait and genetic correlations between traits and to identify new lead PSC risk-associated loci. We identified seven new loci that have not been previously reported and one new independent lead variant in the previously reported locus.
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