Publications by authors named "Matthew A Agnew"
Pharmaceuticals (Basel)
December 2023
Article Synopsis
- Erythropoietic protoporphyria (EPP) is a genetic disorder caused by low levels of ferrochelatase, affecting heme production, while X-linked protoporphyria (XLP) results from overactive δ-aminolevulinic acid synthase 2 (ALAS2), leading to similar symptoms.
- Both conditions cause a buildup of protoporphyrin IX, resulting in extreme sensitivity to light and possible severe liver issues in some patients.
- New treatments like dersimelagon are being developed to improve management options for EPP and XLP beyond traditional methods of sun avoidance.
