Publications by authors named "Matteo Tomasoni"

Background And Study Aim: The development of a new cholangioscope, the SpyGlass™ Discover (Boston Scientific), has allowed the laparoscopic transcystic common bile duct exploration and stone clearance. The possibility of simultaneous treatment of choledocholithiasis during early laparoscopic cholecystectomy offers the opportunity to enormously reduce the time between acute cholecystitis diagnosis and the execution of cholecystectomy with better outcomes for patients. Furthermore, an altered anatomy of the gastrointestinal tract is not an obstacle to this technique.

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The definition of Early Cholecystectomy (EC) is still debatable. This paper aims to find whether the timing of EC affects outcomes. The article reports a multicentric prospective observational study including patients with acute calculous cholecystitis (ACC) who had cholecystectomy within ten days from the onset of symptoms.

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Background: Existing guidelines for predicting common bile duct stones (CBDS) are not specific for acute calculous cholecystitis (ACC). This paper is a posthoc analysis of the S.P.

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Laparotomy incisions provide easy and rapid access to the peritoneal cavity in case of emergency surgery. Incisional hernia (IH) is a late manifestation of the failure of abdominal wall closure and represents frequent complication of any abdominal incision: IHs can cause pain and discomfort to the patients but also clinical serious sequelae like bowel obstruction, incarceration, strangulation, and necessity of reoperation. Previous guidelines and indications in the literature consider elective settings and evidence about laparotomy closure in emergency settings is lacking.

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Article Synopsis
  • Current international guidelines typically exclude patients with colorectal peritoneal carcinosis and a peritoneal cancer index (PCI) of 16 or higher from undergoing surgery.
  • This study retrospectively analyzed outcomes in 71 patients who received cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), finding that those with a higher PCI had longer surgeries and a greater likelihood of incomplete cytoreduction.
  • The results suggest that CRS and HIPEC may still provide reasonable local control for patients with a PCI of 16 or higher, indicating a need to reassess the guidelines that currently exclude these patients from this treatment option.
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  • Recent research highlights the growing use of less invasive treatments for acute calculous cholecystitis (ACC) and seeks a reliable method to identify high-risk patients who may benefit from these alternatives.
  • The S.P.Ri.M.A.C.C. study observed over 1,200 patients across various centers and assessed different preoperative risk prediction models, including the newly validated Chole-risk score.
  • Results indicated that while the Chole-risk score was validated, the POSSUM Physiological Score was found to be the best predictor of complications after early cholecystectomy, demonstrating very high sensitivity for both mortality and major morbidity outcomes.
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Background: Gastric outlet obstruction can result from several benign and malignant diseases, in particular gastric, duodenal or pancreatic tumors. Surgical gastroenterostomy and enteral endoscopic stenting have represented effective therapeutic options, although recently endoscopic ultrasound-guided gastroenterostomy using lumen-apposing metal stent (LAMS) is spreading improving the outcome of this condition. However, this procedure, although mini-invasive, is burdened with not negligible complications, including misdeployment.

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  • Acute left colonic diverticulitis (ALCD) in the elderly differs from younger patients in terms of clinical presentation, higher mortality rates during hospitalization and after surgery, and increased risk from geriatric comorbidities.
  • Despite these risks, elderly patients have a lower chance of recurrent episodes and less likelihood of needing urgent surgery if recurrence occurs.
  • A recent workshop in Italy involving various medical organizations sought to develop age-specific guidelines for diagnosing and treating ALCD in older adults, concluding with expert-approved recommendations on diagnosis, management, surgical techniques, and antibiotic treatment.
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Background: Endoscopic ultrasound-guided drainage is suggested as the first approach in the management of symptomatic and complex walled-off pancreatic necrosis. Dual approach with percutaneous drainage could be the best choice when the necrosis is deep extended till the pelvic paracolic gutter; however, the available catheter could not be large enough to drain solid necrosis neither to perform necrosectomy, entailing a higher need for surgery. Therefore, percutaneous endoscopic necrosectomy through a large bore percutaneous self-expandable metal stent has been proposed.

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Cholangiocarcinoma (CCA) is the second most common primary tumor of the liver, and the recurrence after hepatic resection (HR), the only curative therapy, is linked with a worse prognosis. Systemic chemotherapy (SC) and liver loco-regional treatments, like trans-arterial chemoembolization (TACE) or radio embolization (TARE), have been employed for the treatment of unresectable intrahepatic metastasis (IM) with benefit on overall survival (OS), but SC has a limited effect on peritoneal metastasis (PM). In the last years, novel treatments like electrochemotherapy (ECT) with bleomycine (BLM) for IM and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS and HIPEC) for PM have been applied in small series but with encouraging results.

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Background: In recent years, many studies showed that the Trauma Mortality Probability Model (TMPM-ICD-9) had better calibration compared to other ICD-9-based models and to the ones based to the Abbreviated Injury Scale (AIS). The study aims to assess the validity of TMPM-ICD-9 in predicting injury severity in an Italian region and, through this model, to assess the performances of the Trauma Systems SIAT Romagna.

Methods: Administrative data of trauma patients admitted in the Trauma System of SIAT Romagna, in Northern Italy, from 2014 to 2018 were obtained.

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The epidemiology and the outcomes of acute appendicitis in elderly patients are very different from the younger population. Elderly patients with acute appendicitis showed higher mortality, higher perforation rate, lower diagnostic accuracy, longer delay from symptoms onset and admission, higher postoperative complication rate and higher risk of colonic and appendiceal cancer. The aim of the present work was to investigate age-related factors that could influence a different approach, compared to the 2016 WSES Jerusalem guidelines on general population, in terms of diagnosis and management of elderly patient with acute appendicitis.

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Article Synopsis
  • EndoVascular and Hybrid Trauma Management (EVTM) has been introduced for severe pelvic ring injuries, employing techniques like Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) to manage hemorrhage, though data on its effectiveness is limited.
  • A study of 72 trauma patients with severe pelvic injuries found that most had blunt traumas, with traffic accidents being the most common cause, and REBOA was primarily used in the highest zone of aortic occlusion (zone 1).
  • The overall mortality rate was noted to be 54.2%, with early mortality at 44.4%, influenced by various factors such as pH levels and blood pressure, although these
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Background: Peptic ulcer disease is common with a lifetime prevalence in the general population of 5-10% and an incidence of 0.1-0.3% per year.

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Background: Trauma victims could be an important source of organs. This article presents two cases of successful organ donation and transplant, after Maastricht category III cardiac death in patients with successfully repaired AAST grade V traumatic cardiac injuries.

Case Presentation: The first donor was an adult patient with self-inflicted heart stab wound and non-survivable burn injury.

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Article Synopsis
  • The study investigates the use of open abdomen (OA) techniques in critical patients across Italy, involving 375 patients with an average age of 64 years, mainly for secondary peritonitis and trauma.
  • Key OA methods used included negative pressure wound therapy (nearly 50%) and the Bogotá bag, with an 82.4% success rate in closing the abdomen within about 6 days.
  • High mortality (29.1%) and complication rates (50.8%) were observed; significant factors affecting outcomes included patient age and the presence of pancreatitis.
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Objective: There are very few evidences about safety and usefulness of routine prophylactic ureteral stenting (PUS) before cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).

Material And Methods: An analysis of prospectively collected data about patients who underwent CRS and HIPEC for different sites of primary disease was carried out focusing on ureteral complications.

Results: A total of 138 patients who underwent CRS and HIPEC between December 2010 and June 2017 were considered.

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Background: The World Society of Emergency Surgery (WSES) spleen trauma classification meets the need of an evolution of the current anatomical spleen injury scale considering both the anatomical lesions and their physiologic effect. The aim of the present study is to evaluate the efficacy and trustfulness of the WSES classification as a tool in the decision-making process during spleen trauma management.

Methods: Multicenter prospective observational study on adult patients with blunt splenic trauma managed between 2014 and 2016 in two Italian trauma centers (ASST Papa Giovanni XXIII in Bergamo and Sant'Anna University Hospital in Ferrara).

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Background: No consensus exists among surgeons regarding the optimal treatment of complicated acute appendicitis in children (CAA). Existing studies present heterogeneity of data and only few studies analyzed free perforated appendicitis (FPA) separately from appendicular abscess (AAb) and appendicular phlegmon (AP).

Method: Studies which have been judged eligible for this systematic review and consequent meta-analysis are those comparing non-operative management (NOM) with operative management (OM) in children with CAA.

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Article Synopsis
  • Gastric cancer is a prevalent and deadly disease, with ongoing debate about what constitutes advanced stages of the disease.
  • The best treatment involves radical surgery combined with systemic and intra-abdominal chemotherapy, emphasizing the importance of complete cytoreduction and thorough lymph node removal for better survival rates.
  • There is no conclusive evidence that minimally invasive surgical methods are better than traditional open surgery for treating gastric cancer, especially in advanced cases.
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Several possibilities in treating advanced gastric cancer exist. Radical surgery associated with chemotherapy represents the cornerstone. Which one is more effective among neoadjuvant, adjuvant or perioperative chemotherapy is still a matter of debate.

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Acute appendicitis has been considered by surgeons a progressive disease leading to perforation for more than 100 years. In the last decades the theories about this concept gained attention, especially in adults. However, appendectomy for acute appendicitis remains the most common urgent/emergent surgical procedure.

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Introduction: The majority of patients with splenic trauma undergo non-operative management (NOM); around 15% of these cases fail NOM and require surgery. The aim of the current study is to assess whether the hemodynamic status of the patient represents a risk factor for failure of NOM (fNOM) and if this may be considered a relevant factor in the decision-making process, especially in Centers where AE (angioembolization), intensive monitoring and 24-h-operating room are not available. Furthermore, the presence of additional risk factors for fNOM was investigated.

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