Publications by authors named "Matteo Scita"
A portion of multiple myeloma (MM) patients relapse early or do not respond to first line treatment. Identification of possible clinical and or biological features of these patients remains an unmet medical need. In this study we assesed the predictive markers for early relapse MM, defined as a progressive disease that occurred within 18 months, from autologoust stem cell transplantation (ASCT) in MM patients who did not have primary refractory disease.
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- PEST domain mutations are commonly found in various hematopoietic malignancies, like T-ALL and CLL, and they contribute to tumor development by enhancing Notch signaling, which leads to increased cell growth and survival.* -
- Currently, there is no specific treatment for cancers linked to PEST domain mutations, but several Notch inhibitors, including CAD204520, are under investigation, showing promise in combating T-ALL and increasing sensitivity in CLL and MCL cases with these mutations.* -
- The study demonstrates that CAD204520, especially when combined with existing treatments like venetoclax and ibrutinib, enhances therapeutic efficacy in cancers with PEST mutations, highlighting its potential as a novel treatment strategy for