Publications by authors named "Matteo Colombo"

Article Synopsis
  • Videocapsule endoscopy (VCE) can aid in diagnosing celiac disease (CD) when initial tests are inconclusive and can also be useful in monitoring complex cases.
  • A review of studies showed 186 patients underwent VCE for diagnosis, while 1,337 patients were followed up, highlighting its role in cases with negative serology or persistent symptoms.
  • The findings indicated VCE is effective in identifying complications like refractory CD, but more research is needed for definitive conclusions about its overall utility in CD management.
View Article and Find Full Text PDF

: Subepithelial lesions (SELs) of the gastrointestinal (GI) tract present a diagnostic challenge due to their heterogeneous nature and varied clinical manifestations. Usually, SELs are small and asymptomatic; generally discovered during routine endoscopy or radiological examinations. Currently, endoscopic ultrasound (EUS) is the best tool to characterize gastric SELs.

View Article and Find Full Text PDF

Background: EUS-guided gastroenterostomy (EUS-GE) is a novel and effective procedure for the management of malignant gastric outlet obstruction (GOO) with more durable results when compared to enteral stenting (ES). However, data comparing EUS-GE to ES in patients already treated with EUS-guided choledocoduodenostomy (EUS-CDS) for distal malignant biliary obstruction (DMBO) are lacking. We aimed to compare outcomes of EUS-GE and ES for the palliation of GOO in this specific population of patients.

View Article and Find Full Text PDF

Gastrojejunostomy is the principal method of palliation for unresectable malignant gastric outlet obstructions (GOO). Gastrojejunostomy was traditionally performed as a surgical procedure with an open approach butrecently, notable progress in the development of minimally invasive procedures such as laparoscopic gastrojejunostomies have emerged. Additionally, advancements in endoscopic techniques, including endoscopic stenting (ES) and endoscopic ultrasound-guided gastroenterostomy (EUS-GE), are becoming more prominent.

View Article and Find Full Text PDF

EUS-guided choledochoduodenostomy (EUS-CDS) is a minimally invasive procedure used to treat malignant biliary obstruction (MBO) by transduodenal placement of a lumen-apposing metal stent (LAMS) into the extrahepatic bile duct. To identify factors that contribute to safe and effective EUS-CDS using LAMS, we performed a systematic review of the literature and meta-analysis. The methodology of our analysis was based on PRISMA recommendations.

View Article and Find Full Text PDF

This narrative review provides an overview of the utilization of endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) as a salvage approach in cases of unsuccessful conventional management. EUS-GBD is a minimally invasive and effective technique for drainage in patients with acute cholecystitis with high risk of surgery. The procedure has demonstrated impressive technical and clinical success rates with low rates of adverse events, making it a safe and effective option for appropriate candidates.

View Article and Find Full Text PDF

This review article provides a comprehensive overview of the evolving techniques in image-enhanced endoscopy (IEE) for the characterization of colorectal polyps, and the potential of artificial intelligence (AI) in revolutionizing the diagnostic accuracy of endoscopy. We discuss the historical use of dye-spray and virtual chromoendoscopy for the characterization of colorectal polyps, which are now being replaced with more advanced technologies. Specifically, we focus on the application of AI to create a "virtual biopsy" for the detection and characterization of colorectal polyps, with potential for replacing histopathological diagnosis.

View Article and Find Full Text PDF

Endoscopic retrograde cholangiopancreatography (ERCP) is considered the preferred method for managing biliary obstructions. However, the prevalence of surgically modified anatomies often poses challenges, making the standard side-viewing duodenoscope unable to reach the papilla in most cases. The increasing instances of surgically altered anatomies (SAAs) result from higher rates of bariatric procedures and surgical interventions for pancreatic malignancies.

View Article and Find Full Text PDF
Article Synopsis
  • - Dementia primarily affects elderly populations, with risk factors including pathological, lifestyle, and heritable influences; early diagnosis and management are crucial since there is currently no cure.
  • - The LETHE project focuses on preventing cognitive decline in at-risk elderly individuals using a Big Data platform for personalized risk detection and intervention, aiming to evaluate its effectiveness through a 2-year clinical trial.
  • - LETHE introduces a comprehensive approach to health management by leveraging advanced patient monitoring systems to enhance outcomes, predict cognitive decline, and support adherence to lifestyle interventions.
View Article and Find Full Text PDF
Article Synopsis
  • Benign biliary strictures (BBS) are problems that can happen in the bile ducts due to different conditions in the pancreas or bile system.
  • There are many signs and symptoms that can appear depending on where the strictures are and what causes them.
  • Endoscopic retrograde cholangiopancreatography is a main treatment option, but if it doesn't work, doctors might consider other options like surgery or other procedures.
View Article and Find Full Text PDF

The diagnostic work-up in iron deficiency anaemia (IDA) patients can be challenging when bleedings or malabsorption are not clinically manifest. Lesions on the small bowel mucosa may cause IDA. We evaluated the prevalence of lesions on the small bowel mucosa detected at Videocapsule Endoscopy (VCE) in IDA patients following negative upper and lower endoscopies.

View Article and Find Full Text PDF

Ampullary neoplastic lesions (ANLs) represent a rare cancer, accounting for about 0.6-0.8% of all gastrointestinal malignancies, and about 6-17% of periampullary tumors.

View Article and Find Full Text PDF

Background: Mirroring the experience with colonic resections, cold snare-based techniques have been recently proposed for non-ampullary duodenal lesions to reduce the risk of adverse events (AEs). As the duodenal wall is thinner and more vascularized than in the colon, electrocautery-related AEs are relevant issues in this setting.

Aims: We performed a systematic review with pooled-analysis to evaluate the efficacy and safety of this technique.

View Article and Find Full Text PDF

Where does a probabilistic language-of-thought (PLoT) come from? How can we learn new concepts based on probabilistic inferences operating on a PLoT? Here, I explore these questions, sketching a traditional circularity objection to LoT and canvassing various approaches to addressing it. I conclude that PLoT-based cognitive architectures can support genuine concept learning; but, currently, it is unclear that they enjoy more explanatory breadth in relation to concept learning than alternative architectures that do not posit any LoT.

View Article and Find Full Text PDF

This narrative review provides an overview of the application of endoscopic ultrasound-guided biliary drainage (EUS-BD), including EUS-guided gallbladder drainage (EUS-GBD), for the treatment of malignant biliary obstruction. EUS-BD has demonstrated excellent technical and clinical success rates, with lower rates of adverse events when compared with percutaneous trans-hepatic biliary drainage (PTBD). EUS-BD is currently the preferred alternative technique for biliary drainage (BD) in patients with distal malignant biliary obstruction (DMBO) after failed endoscopic retrograde cholangiopancreatography (ERCP).

View Article and Find Full Text PDF

Background And Aims: Differentiating pancreatic cystic lesions (PCLs) remains a diagnostic challenge. The use of high-definition imaging modalities which detect tumor microvasculature have been described in solid lesions. We aim to evaluate the usefulness of cystic microvasculature when used in combination with cyst fluid biochemistry to differentiate PCLs.

View Article and Find Full Text PDF

Background: There is limited evidence on the comparative diagnostic performance of endoscopic tissue sampling techniques for subepithelial lesions. We performed a systematic review with network meta-analysis to compare these techniques.

Methods: A systematic literature review was conducted for randomized controlled trials (RCTs) comparing the sample adequacy and diagnostic accuracy of bite-on-bite biopsy, mucosal incision-assisted biopsy (MIAB), endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), and EUS-guided fine-needle biopsy (FNB).

View Article and Find Full Text PDF

Background: Endoscopic Ultrasound (EUS) is widely used for the diagnosis of bilio-pancreatic and gastrointestinal (GI) tract diseases, for the evaluation of subepithelial lesions, and for sampling of lymph nodes and solid masses located next to the GI tract. The role of Artificial Intelligence in healthcare in growing. This review aimed to provide an overview of the current state of AI in EUS from imaging to pathological diagnosis and training.

View Article and Find Full Text PDF

Due to the high risk of morbidity and mortality associated with surgical resection in this tract, endoscopic resection (ER) has taken the place of surgical resection as the first line treatment for non-ampullary duodenal adenomas. However, due to the anatomical characteristics of this area, which enhance the risk of post-ER problems, ER in the duodenum is particularly difficult. Due to a lack of data, no ER technique for superficial non-ampullary duodenal epithelial tumours (SNADETs) has yet been backed by strong, high-quality evidence; yet, traditional hot snare-based techniques are still regarded as the standard treatment.

View Article and Find Full Text PDF

Over the last two decades, endoscopic eradication therapy has been established as the therapeutic strategy of choice for patients with Barrett's oesophagus-related dysplasia and early oesophageal adenocarcinoma. With a multimodal approach, ablative therapies have been highly effective in achieving remarkable eradication rates of metaplastic epithelium with an acceptable adverse event rate. Among ablative techniques, radiofrequency ablation is currently considered as the first-line option as its efficacy and safety are strongly supported by relevant data.

View Article and Find Full Text PDF

Background: Duodenoscope-related multidrug-resistant organism (MDRO) infections raise concerns. Disposable duodenoscopes have been recently introduced in the market and approved by regulatory agencies with the aim to reduce the risk of endoscopic retrograde cholangiopancreatography (ERCP) associated infections. The aim of this study was to evaluate the outcome of procedures performed with single-use duodenoscopes in patients with clinical indications to single-operator cholangiopancreatoscopy.

View Article and Find Full Text PDF
Article Synopsis
  • The study evaluated the effectiveness and safety of EUS-guided fine-needle biopsy (EUS-FNB) in diagnosing lymphadenopathies, involving 100 patients from various institutions.
  • It found that EUS-FNB had high diagnostic accuracy, with sensitivity at 96.2% and no recorded adverse events, making it a reliable method for obtaining histological samples.
  • The new end-cutting needles used in the procedure provided sufficient tissue for detailed analysis of conditions like metastatic lymphadenopathy and lymphomas.
View Article and Find Full Text PDF

Inflammatory bowel diseases, namely ulcerative colitis and Crohn's disease, are chronic and relapsing conditions that pose a growing burden on healthcare systems worldwide. Because of their complex and partly unknown etiology and pathogenesis, the management of ulcerative colitis and Crohn's disease can prove challenging not only from a clinical point of view but also for resource optimization. Artificial intelligence, an umbrella term that encompasses any cognitive function developed by machines for learning or problem solving, and its subsets machine learning and deep learning are becoming ever more essential tools with a plethora of applications in most medical specialties.

View Article and Find Full Text PDF