The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms.

Paramyxovirus membrane fusion requires an attachment protein for receptor binding and a fusion protein for membrane fusion triggering. Nipah virus (NiV) attachment protein (G) binds to ephrinB2 or -B3 receptors, and fusion protein (F) mediates membrane fusion. NiV-F is a class I fusion protein and is activated by endosomal cleavage.

[Design and rationale: Observational Study of the Argentine Group for the Study of Lipoprotein (a)].

Introduction: Elevated levels of Lipoprotein(a) [Lp(a)] have been linked to increased cardiovascular risk globally. However, comprehensive studies on Lp(a) levels and their impact on cardiovascular health in Argentina are lacking. The Argentine Group for the Study of Lipoprotein (a) [GAELp(a)] aims to address this gap through an observational study designed to evaluate the prevalence and consequences of elevated Lp(a) levels in the Argentine population.

Chronic Total Occlusion of the Left Main and Severe Aortic Stenosis.

Concomitant aortic stenosis and coronary artery disease in the elderly population is frequent and the proper therapeutic approach is a matter of debate. We present 2 challenging cases of patients affected by severe aortic stenosis and chronic total occlusion of the left main, demonstrating the safety and feasibility of transcatheter aortic valve replacement, performed both with balloon-expandable and self-expanding valves.

Pregnant women's perceptions on Information Sources on Zika Virus: a qualitative study.

The Zika virus (ZIKV) epidemic had a sanitary, psychosocial, and economic impact on individuals of reproductive age. The primary concern revolved around infection during pregnancy due to possible vertical transmission and its association with adverse fetal and infant outcomes, known as Congenital Zika Syndrome (CZS). This qualitative study employs phenomenology and grounded theory.

"I found out about Zika virus after she was born." Women's experiences of risk communication during the Zika virus epidemic in Brazil, Colombia, and Puerto Rico.

Providing accurate, evidence-based information to women with Zika infection during pregnancy was problematic because of the high degree of uncertainty in the diagnosis of the infection and the associated risk. The 2015-17 Zika virus epidemic overwhelmingly affected women in countries with limited access to safe abortion. Understanding women's perspectives on risk communication during pregnancy in the context of an emerging pathogen can help inform risk communication in response to future outbreaks that affect fetal or child development.

[Childhood vaccine hesitancy and COVID-19: an analysis based on the perception of health professionals].

This article presents the results of a study on health professionals' perceptions of childhood vaccine hesitancy related to COVID-19. Based on the theoretical construct of vaccine hesitancy, a qualitative study was conducted with 86 primary health care (PHC) workers in four municipalities in four Brazilian states and in the Federal District. A thematic analysis was performed and three categories were obtained: fear, misinformation about vaccines, and the role of health professionals.

Pre-TAVI imaging: an Italian survey by the CT PRotocol optimization (CT-PRO) group.

Purpose: The purpose of this survey was to evaluate the current state-of-art of pre-TAVI imaging in a large radiological professional community.

Methods: Between December 2022 and January 2023 all members of the Italian Society of Medical and Interventional Radiology (SIRM) were invited by the CT PRotocol Optimization group (CT-PRO group) to complete an online 24-item questionnaire about pre-TAVI imaging.

Results: 557 SIRM members participated in the survey.

A rapid qualitative methods assessment and reporting tool for epidemic response as the outcome of a rapid review and expert consultation.

During the first year of the COVID-19 pandemic, the Methods Sub-Group of the WHO COVID-19 Social Science Research Roadmap Working Group conducted a rapid evidence review of rapid qualitative methods (RQMs) used during epidemics. The rapid review objectives were to (1) synthesize the development, implementation, and uses of RQMs, including the data collection tools, research questions, research capacities, analytical approaches, and strategies used to speed up data collection and analysis in their specific epidemic and institutional contexts; and (2) propose a tool for assessing and reporting RQMs in epidemics emergencies. The rapid review covered published RQMs used in articles and unpublished reports produced between 2015 and 2021 in five languages (English, Mandarin, French, Portuguese, and Spanish).

Sodium Bicarbonate and Time-to-Exhaustion Cycling Performance: A Retrospective Analysis Exploring the Mediating Role of Expectation.

Background: Research has shown that ingesting 0.3 g·kg body mass sodium bicarbonate (NaHCO) can improve time-to-exhaustion (TTE) cycling performance, but the influence of psychophysiological mechanisms on ergogenic effects is not yet understood.

Objective: This study retrospectively examined whether changes in TTE cycling performance are mediated by positive expectations of receiving NaHCO and/or the decline in blood bicarbonate during exercise.

Assessment of potentially toxic elements in groundwater through interpolation, pollution indices, and chemometric techniques in Dehradun in Uttarakhand State.

Providing safe drinking water for the entire world's population is essential for ensuring sustainable development. The presence of harmful compounds in aquifers, majorly toxic elements, is a serious environmental concern around the globe. This research aimed to quantify for the initial period the amounts of toxic elements in freshwater in the Dehradun Industrial Region of Uttrakhand, India, as well as the associated health risks.

Capacity analysis of underwater visible light communication systems over a lossy channel in the presence of noises.

Absorption and scattering losses due to impurities and turbidity in the water affect the transmission quality of underwater visible light communication links, restricting the channel capacity. For the first time to our knowledge, this paper analytically studies the channel capacity of a point-to-point underwater visible light communication link in the presence of input-independent and -dependent noises along with absorption and scattering losses. This way, novel lower and upper bound expressions on channel capacity are derived when average and peak-intensity constraints are imposed on the channel input.

Hydrochemical characterization of groundwater quality using chemometric analysis and water quality indices in the foothills of Himalayas.

Groundwater pollution of the watershed is mainly influenced by the multifaceted interactions of natural and anthropogenic process. To analyse the spatial-temporal variation and pollution source identification and apportionment, the dataset was subjected to a globally acknowledged coherent technique using water quality indices and chemometric techniques (principal component analysis (PCA) and cluster analysis. The bulk of the samples tested were below the BIS's permissible levels.

Efficacy of sodium bicarbonate ingestion strategies for protecting blinding.

Sodium bicarbonate (NaHCO) is a widely researched ergogenic aid, but the optimal blinding strategy during randomised placebo-controlled trials is unknown. In this multi-study project, we aimed to determine the most efficacious ingestion strategy for blinding NaHCO research. During study one, 16 physically active adults tasted 0.

Seizure Outcome of Temporal Lobe Epilepsy Surgery in Adults and Children: A Systematic Review and Meta-Analysis.

Background: Temporal lobe epilepsy (TLE) surgery is associated with the best seizure outcome in adults, although its long-term results remain suboptimal. Retrospective pediatric studies suggest better figures whose determinants are poorly understood.

Objective: To conduct a systematic review and meta-analysis of studies on the efficacy of TLE surgery in children (age younger than 18 years) and adults.

Communicating Water, Sanitation, and Hygiene under Sustainable Development Goals 3, 4, and 6 as the Panacea for Epidemics and Pandemics Referencing the Succession of COVID-19 Surges.

WASH (water, sanitation, and hygiene) has become the most crucial amenity in the past decade for every individual on the planet. In the UN agenda for 2030, which created 17 Sustainable Development Goals (SDGs), SDGs 3, 4, and 6 directly correlate with WASH practices and management for creating a good health hygiene environment for all. The dearth of WASH facilities has created barriers for averting the transmission of COVID-19, motivating the concept of WASH as the primary step of precaution and prevention, which includes WASH practices, communication for literacy, and positive behavioral changes primarily in developing and low-income countries.

Reproducibility of 20-min Time-trial Performance on a Virtual Cycling Platform.

This study aimed to analyse the reproducibility of mean power output during 20-min cycling time-trials, in a remote home-based setting, using the virtual-reality cycling software, Zwift. Forty-four cyclists (11 women, 33 men; 37±8 years old, 180±8 cm, 80.1±13.

CT or Invasive Coronary Angiography in Stable Chest Pain.

Background: In the diagnosis of obstructive coronary artery disease (CAD), computed tomography (CT) is an accurate, noninvasive alternative to invasive coronary angiography (ICA). However, the comparative effectiveness of CT and ICA in the management of CAD to reduce the frequency of major adverse cardiovascular events is uncertain.

Methods: We conducted a pragmatic, randomized trial comparing CT with ICA as initial diagnostic imaging strategies for guiding the treatment of patients with stable chest pain who had an intermediate pretest probability of obstructive CAD and were referred for ICA at one of 26 European centers.

Three heads are better than one: Psychiatry trainees' experiences of a psychotherapy written case supervision group with three co-supervisors.

Objective: The aim of this project was to evaluate the experiences of Royal Australian and New Zealand College of Psychiatrists (RANZCP) trainees in a regional centre who participated in a psychodynamic psychotherapy written case supervision group with three co-supervisors.

Method: A web-based survey was sent to RANZCP trainees. Descriptive statistics were performed, and written feedback was analysed.

A coherent approach of Water Quality Indices and Multivariate Statistical Models to estimate the water quality and pollution source apportionment of River Ganga System in Himalayan region, Uttarakhand, India.

River Ganga covers around 26% of India's land area and sustains diverse ecosystems in this overly populated area. The globally accepted coherent approach of water quality indices (WQIs) and multivariate statistical models (principal component analysis (PCA) and cluster analysis (CA)) were applied on the dataset to evaluate the spatial-temporal variation and pollution source identification and apportionment. Twenty-two hydro-chemical parameters were analyzed by collecting the samples from 20 different vertically elevated monitoring locations for different seasons.