Publications by authors named "Matt Hardy"
We have generated an improved assembly and gene annotation of the pig X Chromosome, and a first draft assembly of the pig Y Chromosome, by sequencing BAC and fosmid clones from Duroc animals and incorporating information from optical mapping and fiber-FISH. The X Chromosome carries 1033 annotated genes, 690 of which are protein coding. Gene order closely matches that found in primates (including humans) and carnivores (including cats and dogs), which is inferred to be ancestral.
View Article and Find Full Text PDFElectrophysiological properties and molecular background of the zebrafish (Danio rerio) cardiac inward rectifier current (IK1) were examined. Ventricular myocytes of zebrafish have a robust (-6.7 ± 1.
View Article and Find Full Text PDFArticle Synopsis
- Copy number variants (CNVs) are significant in human genetic diversity and may influence susceptibility to common diseases.
- A study analyzed around 19,000 individuals for associations between CNVs and eight common diseases using a specialized array that covered many polymorphic CNVs.
- The findings indicated that while some CNV loci were linked to diseases, they largely overlap with previously identified single nucleotide polymorphisms (SNPs), suggesting that common CNVs may not play a major role in the genetic underpinnings of these diseases.
Efforts to adapt and extend graphic arts printing techniques for demanding device applications in electronics, biotechnology and microelectromechanical systems have grown rapidly in recent years. Here, we describe the use of electrohydrodynamically induced fluid flows through fine microcapillary nozzles for jet printing of patterns and functional devices with submicrometre resolution. Key aspects of the physics of this approach, which has some features in common with related but comparatively low-resolution techniques for graphic arts, are revealed through direct high-speed imaging of the droplet formation processes.
View Article and Find Full Text PDF