FIAT: A Device for Objective, Optical Measures of Accommodation in Phakic and Pseudophakic Eyes.

Purpose: To present FIAT, a novel optical instrument and analysis package that is designed to elicit and optically record accommodation in human eyes.

Methods: FIAT employs a Shack-Hartmann wavefront sensor and a retro-illumination pupil camera that records from a single eye at video rates. It is effective at eliciting accommodation by offering the subject a full-field binocular view of an alternating distant target and a near-eye display.

Redox Chemistry and the Role of Trapped Molecular O in Li-Rich Disordered Rocksalt Oxyfluoride Cathodes.

In the search for high energy density cathodes for next-generation lithium-ion batteries, the disordered rocksalt oxyfluorides are receiving significant attention due to their high capacity and lower voltage hysteresis compared with ordered Li-rich layered compounds. However, a deep understanding of these phenomena and their redox chemistry remains incomplete. Using the archetypal oxyfluoride, LiMnOF, we show that the oxygen redox process in such materials involves the formation of molecular O trapped in the bulk structure of the charged cathode, which is reduced on discharge.

Molecular and immunological features of a prolonged exceptional responder with malignant pleural mesothelioma treated initially and rechallenged with pembrolizumab.

Background: This case represents an exceptional response to pembrolizumab in a patient with epithelioid mesothelioma with a further response on rechallenge.

Case Presentation: A 77-year-old woman with advanced epithelioid mesothelioma extensively pretreated with chemotherapy demonstrated a prolonged response of 45 months to 52 cycles of pembrolizumab. On rechallenge with pembrolizumab, further disease stability was achieved.