[Microbiological analysis of the state of environment in the Orenburg region].

The frequency of the residual staphylococcal carriage among the children who live in rural area having different levels and patterns of environmental pollution is estimated. A relationship is found between the frequency of the residual staphylococcal carriage and the rate of technogenic pollution of the ambient air. The findings suggest that the staphylococcal carriage among children may be used as an index of the unfavorable environment.

[A nutrient medium for the isolation of staphylococci with persistence characteristics].

A new selective medium with fusidine for isolation of persistent staphylococci is developed and tried. The medium can be used for detecting the agent (staphylococcus) in mixed microflora in infectious diseases, in screenings for resident Staphylococcus carriership, in bioindication of air contamination, for predicting the course and for monitoring rational therapy of pyoinflammatory diseases in humans and animals in medicine and veterinary.

[Prognosis of postinjection abscesses course with use of mathematical model].

Virulent and persistent characteristics of staphylococci isolated from 100 patients with various types of course of the abscessed forms of postinjection suppuration were defined. Comparative analysis of 11 biological characteristics of the microorganisms was carried out. An important role of the complex of properties of Staphylococcus aureus was established, including lysozyme, proteolytic, fibrinolytic activities, ability for inactivation of immunoglobulins through their Fc-receptors' binding to protein A, antilysozyme, "antiinterferon", anticomplement activities in determination of protracted character of festering and inframmatory process initiated by them.

[Staphylococcal persistence factors in the prognostication of the course of pyo-inflammatory diseases].

The role of Staphylococcus aureus persistence factors as the most informative signs of bacteria in the determination of the specific features of purulent inflammatory diseases has been established. The model for the prognostication of the character of the course of the purulent inflammatory process, induced by staphylococci, with due regard to the complex of their persistence factors has been created.

[The association of biological properties of staphylococci with the process of purulent sinusitis].

The study of the relationship of biological characteristics of staphylococci initiating the inflammation with features of clinical course of maxillary sinusitis has found that staphylococci with virulent characteristics determine acute course of the disease whereas the strains with persistent properties cause chronic course of maxillary sinusitis. Clinical isolates from the purulent discharge and the strains vegetating on the mucosa of the anterior part of the nose appeared identical.

[The role of Staphylococcus epidermidis persistence factors in the infectious process].

The species composition of microflora was determined and the etiological role of S. epidermidis was shown in some purulent inflammatory diseases (maxillary sinusitis, urethritis). The role of the complex of S.

[The dynamics of the persistence characteristics of staphylococci under the action of the microclimate of a speleotherapy mine].

A decrease in the persistence characteristics of staphylococci under the influence of microclimate in a spelean pit has been demonstrated under experimental conditions. Clinical investigations have confirmed the capacity of speleotherapy to decrease the microbial contamination of the upper respiratory tract and to inhibit the persistence properties of staphylococcal microflora in children with respiratory allergosis, which seems to be the basis of the positive effect achieved by treatment with microclimate in a spelean pit.

[The resident staphylococcal bacterial carriage in a human population as an index for the microecological monitoring of its habitat environment].

The informative character of staphylococcal persistence factors (antilysozyme and "anti-interferon" signs) as the indices of resident staphylococcal carrier state in the microecological monitoring of the aerial environment was determined. In areas, ecologically unfavorable with respect to the occurrence of diseases of respiratory organs and to the level of air pollution, staphylococcal strains with persistence factors were isolated from children 3 times as often as in areas with low levels of morbidity in respiratory diseases and environmental pollution. The background level resident staphylococcal carrier state was determined (8.

[The construction of a diagnostic model for the differentiation of resident and transient staphylococcal microflora in bacterial carriage].

The comparative analysis of 16 biological characteristics of staphylococci isolated from specially selected groups of persons with different types of carrier state has been made. Five signs (antilysozyme, anti-interferon and anticomplementary activities, sensitivity to fusidin, microbial contamination) forming the main informative combination have been determined. The diagnostic model of the differentiation of resident and transitory staphylococcal microflora in carrier state has been developed.

[The characteristics of the formation of the staphylococcal landscape in the nasal mucosa of different types of bacterial carriers].

The complex study of factors of persistence, virulence and antagonism in 473 coagulase-positive (CP) staphylococci and 489 coagulase-negative (CN) staphylococci inhabiting the nasal mucosa of resident and transitory carriers, and not carriers of CP staphylococci, was made. In the selection of virulent strains of CP staphylococci the factor of anti-interferon activity seemed to be of greater importance than the factor of antilysozyme activity, but the latter was preferable in the selection of virulent strains of CN staphylococci. Biovars of CP staphylococci with a set of factors of persistence, virulence and antagonism were isolated from resident carriers 1.