Publications by authors named "Matin Kohsar"
Respiratory infections are one of the most common causes of death among children under the age of five years. Data on prevalence and relevance of specific organisms in African children are still lacking. This case-control-study investigated prevalence and relevance of specific organisms in Ghanaian children admitted to hospital with symptoms of lower respiratory tract infection (LRTI).
View Article and Find Full Text PDF[This corrects the article DOI: 10.1371/journal.ppat.
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- - The study analyzed SARS-CoV-2-specific T cell responses in 34 individuals (10 with acute and 24 with resolved COVID-19) by testing 135 overlapping peptides from the virus's envelope, membrane, and nucleoprotein using methods like ELISpot and intracellular cytokine staining.
- - A significant majority (97%) of participants showed CD4+ T cell responses to these peptides, with an average of 21.7 specific responses per patient and 10 identified peptides with over 36% response frequency.
- - Notably, three peptides (Mem_P30, Mem_P36, and Ncl_P18) induced responses in over 55% of patients, leading to the development of a new tet
HDV is a small, defective RNA virus that requires the HBsAg of HBV for its assembly, release, and transmission. Chronic HBV/HDV infection often has a severe clinical outcome and is difficult to treat. The important role of a robust virus-specific T cell response for natural viral control has been established for many other chronic viral infections, but the exact role of the T cell response in the control and progression of chronic HDV infection is far less clear.
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- The study investigates the impact of metabolic and cardiovascular diseases on liver disease progression in chronic hepatitis B (CHB) patients, revealing a significant rise in liver cirrhosis and related events in those with these comorbidities.
- A retrospective analysis of 602 CHB patients showed that those with diabetes, obesity, hypertension, or coronary heart disease had higher rates of cirrhosis and liver-related incidents during a median follow-up of 2.51 years.
- The findings highlight that hepatitis B patients with metabolic disorders, particularly diabetes, require closer monitoring and tailored treatment strategies due to their increased risk of severe liver complications.
B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation. In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals. As a main result, we observed an increase of the frequency of (CD27, CD21) atypical memory B cells and (CD19, CD27, CD38) plasmablasts in malaria and COVID-19 patients.
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- The ectonucleotidases CD39 and CD73 are crucial in regulating immune responses by controlling the balance of ATP and adenosine during inflammation, potentially impacting COVID-19 pathology.
- A study found that COVID-19 patients had significantly lower CD73 expression in their cytotoxic lymphocytes (like CD8 T cells, NKT, and NK cells) compared to healthy individuals, with the decrease linked to higher serum ferritin levels.
- CD8 T cells and NKT cells without CD73 exhibited greater cytotoxic functions, indicating the need for further research on CD39 and CD73 in various disease stages and their use as potential therapeutic targets.