Publications by authors named "Matilde Winther-Jensen"

Functional somatic disorders (FSDs) are a unifying diagnosis that includes functional somatic syndromes (FSSs) as well as the unifying diagnostic construct of bodily distress syndrome (BDS). FSDs are characterized by persistent and troublesome physical symptoms that are prevalent across all medical settings and for which no clinical tests can establish a definitive diagnosis. The aim of this study was to explore associations between BDSs and objective measurements of body composition, cardiorespiratory health, and physical performance.

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Background And Aims: Extrahepatic comorbidities are common in alcohol-related liver disease (ALD). We examined associations between burden of comorbidities, alcohol, and smoking with low health-related quality of life (HRQoL) among patients with ALD.

Methods: Patients with ALD and matched comparators were identified among respondents of the Danish National Health Survey waves in 2010-2017.

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Background: Studying complete hospital care episodes from register data, for instance when assessing length of stay, discharges and readmissions, can cause methodological difficulties due to the lack of a contact linkage identifier. We aimed to develop an algorithm combining sequential attendance contacts in the Danish National Patient Register (DNPR) into hospital care episodes, spanning the entire duration and all contacts from hospital arrival to departure.

Methods: The algorithm was developed under the consensus of experts from research institutions across Denmark.

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Background And Purpose: Dislocation is a severe complication following total hip arthroplasty (THA). Hip precautions have been recommended in the initial postoperative period but evidence supporting this practice is limited. We therefore conducted a population-based study to evaluate the association between discontinuing recommending postoperative hip precautions and the risk of early dislocation.

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Article Synopsis
  • Acute kidney injury (AKI) significantly impacts long-term survival rates in patients who experience out-of-hospital cardiac arrest (OHCA), raising questions about its role as a primary risk factor versus a marker of initial condition severity.
  • A study involving 759 comatose OHCA patients categorized them based on AKI severity using the KDIGO classification and assessed their survival rates over 365 days using adjusted Cox regression models.
  • Results indicated that patients with AKI, whether requiring continuous kidney replacement therapy (CKRT) or not, had markedly lower survival rates compared to those without AKI, with similar hazard ratios indicating a consistent risk associated with both AKI groups.
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Background: Alcohol-related liver disease is a preventable disease with high mortality. If individuals with alcohol-related liver disease were to be diagnosed earlier by screening and they reduced their alcohol consumption, lives lost to alcohol-related liver disease might be saved. A liver stiffness measurement (FibroScan©) is a key tool to screen for alcohol-related liver disease in asymptomatic individuals.

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Introduction: Bile acid diarrhea (BAD) is an underrecognized and socially debilitating disease caused by high concentrations of bile acids in the colon. Bile acids directly and indirectly promote carcinogenesis. In this article, we investigated whether individuals with BAD have an increased risk of gastrointestinal (GI) cancers.

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Introduction: Most cardiac arrest survivors are classified with mild to moderate cognitive impairment; roughly, 50% experience long-term neurocognitive impairment. Postarrest challenges complicate participation in society and are associated with social issues such as failure to resume social activities and impaired return to work. The effectiveness of rehabilitation interventions for out-of-hospital cardiac arrest survivors are sparsely described, but the body of evidence describes high probabilities of survivors not returning to work, returning to jobs with modified job descriptions, returning to part-time employment, and often in combination with extensive unmet rehabilitation needs.

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Article Synopsis
  • - The BOX trial examined the effects of different blood pressure and oxygenation targets, as well as varying durations of fever prevention, on the health outcomes of comatose patients after cardiac arrest, ultimately finding no significant differences in long-term disability or mortality rates.
  • - Conducted as a randomized controlled trial, 789 patients were assigned to either low or high blood pressure targets, restrictive or liberal oxygenation levels, and differing durations of fever control, with a one-year follow-up for mortality.
  • - Results showed similar one-year mortality rates across all tested interventions, indicating that neither the low/high blood pressure nor the restrictive/liberal oxygenation strategies significantly impacted patient survival outcomes after one year.
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Objective: Bile acid diarrhea (BAD) is a socially debilitating disease with frequent bowel movements, urgency, and fecal incontinence as the main symptoms. It is caused by excessive bile acid levels in the colon and is most commonly treated with bile acid sequestrants. It is estimated that 1-2% of the population suffers from the disease, but only a fraction of these are properly diagnosed with the gold standard ⁷⁵selenium-homotaurocholic acid (SeHCAT) test.

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Background: Out-of-hospital cardiac arrest (OHCA) survivors remaining comatose are often circulatory unstable with high mortality in the first days following resuscitation. Elevated lactate will reflect the severity and duration of hypoperfusion in cardiac arrest. Further, the severity of hypoperfusion could modify the effect on survival of different mean arterial blood pressure (MAP) targets.

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Aim: To explore the impact of type 2 diabetes (T2D), glycaemic control and use of glucose-lowering medication on clinical outcomes in hospitalized patients with COVID-19.

Materials And Methods: For all patients admitted to a hospital in the Capital Region of Denmark (1 March 2020 to 1 December 2021) with confirmed COVID-19, we extracted data on mortality, admission to intensive care unit (ICU), demographics, comorbidities, medication use and laboratory tests from the electronic health record system. We compared patients with T2D to patients without diabetes using Cox proportional hazards models adjusted for available confounding variables.

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Article Synopsis
  • Acute kidney injury (AKI) is a serious concern following out-of-hospital cardiac arrest, and this study investigates how different blood pressure and oxygenation targets during post-resuscitation care affect AKI risk.
  • The study involved 789 comatose adult patients and compared two blood pressure targets (63 vs. 77 mm Hg) and two oxygen targets (9-10 kPa vs. 13-14 kPa) to determine AKI incidence based on KDIGO criteria.
  • Results showed that patients with low blood pressure and liberal oxygen target had a higher risk (44% vs. 30%) of developing mild-stage AKI, although plasma creatinine levels did not differ significantly at the 6- and 12
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Previous studies showed that alpha/delta ratio neurofeedback was effective in reducing unpleasant psychological, emotional and perceptual consequences of tinnitus. The main goal of the present study was to investigate, whether the specific combination of enhancing alpha frequency band activity and reducing delta frequency band activity was necessary, or merely sufficient, to obtain a positive treatment outcome regarding tinnitus distress and intensity. A second research aim was to assess the relative contribution of neurofeedback-related non-specific and general non-specific effects in neurofeedback treatment.

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Article Synopsis
  • Troponin levels above the reference range indicate a higher risk of mortality in patients with pulmonary embolism (PE), suggesting a potential dose-response relationship.
  • A study involving 5,639 PE patients revealed that higher troponin concentrations correlate with increasing 30-day mortality rates, from 1% in the lowest quintile to 15% in the highest.
  • The findings underscore the importance of troponin measurements for better risk assessment and management of PE patients, particularly regarding treatment strategies and outcomes.
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Purpose: Revision rates following primary knee arthroplasty vary by country, region and hospital. The SPARK study was initiated to compare primary surgery across three Danish regions with consistently different revision rates. The present study investigated whether the variations were associated with differences in the primary patient selection.

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Purpose: It is well-known that revision rates after primary knee arthroplasty vary widely. However, it is uncertain whether hospital revision rates are reliable indicators of general surgical quality as defined by patients. The SPARK study compared primary knee arthroplasty surgery at three high-volume hospitals whose revision rates differed for unknown reasons.

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To review studies examining the appendiceal microbiota and microbial changes in acute appendicitis. After a systematic literature search, 11 studies examining the appendiceal microbiota (414 samples) using non-culture-based methods were included. The appendiceal microbiota showed decreased α-diversity compared with fecal microbiota.

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Objective: To identify PaCO trajectories and assess their associations with mortality in critically ill patients with coronavirus disease 2019 (COVID-19) during the first and second waves of the pandemic in Denmark.

Design: A population-based cohort study with retrospective data collection.

Patients: All COVID-19 patients were treated in eight intensive care units (ICUs) in the Capital Region of Copenhagen, Denmark, between March 1, 2020 and March 31, 2021.

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Background & Aims: The function and structure of social relationships influence mortality in individuals within the general population. We compared aspects of social relationships in individuals with cirrhosis and a matched comparison cohort and studied their association with health-related quality of life (HRQoL) and mortality in cirrhosis.

Methods: Individuals with cirrhosis and comparators were identified among participants of the Danish National Health Surveys 2010-2017.

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  • Guidelines recommend active fever prevention for 72 hours after cardiac arrest, but evidence from clinical trials on its effectiveness is lacking.
  • In a study of comatose patients resuscitated after cardiac arrest, researchers compared temperature control interventions for either 36 or 72 hours.
  • The results showed no significant differences in mortality or disability rates between the two groups at 90 days, indicating that fever prevention for 36 hours could be as effective as 72 hours.
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Aims: In refractory out-of-hospital cardiac arrest (OHCA) with prolonged whole-body ischaemia, global tissue injury proceeds even after establishment of circulation with extracorporeal cardiopulmonary resuscitation (ECPR). We aimed to investigate the role of biomarkers reflecting hypoperfusion, inflammation, and organ injury in prognostication of patients with refractory OHCA managed with ECPR.

Methods And Results: This nationwide retrospective study included 226 adults with refractory OHCA managed with ECPR in Denmark (2011-2020).

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Background: The appropriate oxygenation target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest is unknown.

Methods: In this randomized trial with a 2-by-2 factorial design, we randomly assigned comatose adults with out-of-hospital cardiac arrest in a 1:1 ratio to either a restrictive oxygen target of a partial pressure of arterial oxygen (Pao) of 9 to 10 kPa (68 to 75 mm Hg) or a liberal oxygen target of a Pao of 13 to 14 kPa (98 to 105 mm Hg); patients were also assigned to one of two blood-pressure targets (reported separately). The primary outcome was a composite of death from any cause or hospital discharge with severe disability or coma (Cerebral Performance Category [CPC] of 3 or 4; categories range from 1 to 5, with higher values indicating more severe disability), whichever occurred first within 90 days after randomization.

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